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Synfacts 2011(2): 0228-0228  
DOI: 10.1055/s-0030-1259364
Polymer-Supported Synthesis
© Georg Thieme Verlag Stuttgart ˙ New York

Dehydration of Amides with Hydrotalcite-Supported Vanadium Catalyst

Contributor(s): Yasuhiro Uozumi, Takao Osako
S. Sueoka, T. Mitsudome, T. Mizugaki, K. Jitsukawa, K. Kaneda*
Osaka University, Toyonaka, Japan
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Publication History

Publication Date:
19 January 2011 (online)

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Significance

Monomeric vanadium oxide supported on hydrotalcite (V/HT) was prepared by treatment of VCl3 with hydrotalcite in water (eq. 1). V/HT catalyzed the dehydration of amides in ­mesitylene under reflux conditions to give the ­corresponding nitriles in 50 to >99% yield (16 examples, eq. 2). In the dehydration of ortho-toluamide, the catalyst was recovered by simple filtration and reused twice without significant loss of activity.