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Synfacts 2011(4): 0355-0355  
DOI: 10.1055/s-0030-1259588
Synthesis of Natural Products and Potential Drugs
© Georg Thieme Verlag Stuttgart ˙ New York

Synthesis of Triple Reuptake Inhibitor GSK1360707F

Contributor(s): Philip Kocienski
N. M. Deschamps, V. I. Elitzin*, B. Liu, M. B. Mitchell, M. J. Sharp, E. A. Tabet
GlaxoSmithKline, Research Triangle Park, USA
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Publication History

Publication Date:
18 March 2011 (online)

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Significance

(-)-GSK1360707F is a serotonin-noradrenaline-dopamine triple reuptake inhibitor under development for the treatment of severe ­depression. In this short synthesis of racemic GSK1360707F, the 3-azabicyclo[4.1.0]heptane framework was constructed in quantitative yield via a platinum(II)-catalyzed enyne cycloisomerization (E → F).