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Synfacts 2011(4): 0356-0356  
DOI: 10.1055/s-0030-1259639
Synthesis of Natural Products and Potential Drugs
© Georg Thieme Verlag Stuttgart ˙ New York

Biomimetic Synthesis of (±)-Rossinone B

Contributor(s): Steven V. Ley, Sean Newton
Z. Zhang, J. Chen, Z. Yang*, Y. Tang*
Peking University, Beijing and Tsinghua University, Beijing, P. R. of China
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Publication History

Publication Date:
18 March 2011 (online)

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Significance

Rossinone B was isolated from a marine organism of the ascidian Aplidium species in 2009. It exhibits potent antiviral, anti-inflammatory, and antileukemic activity. The above synthesis was designed around a proposed biosynthesis of rossinone B as well as a model study on the key vinyl quinone Diels-Alder reaction.