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Synfacts 2011(4): 0413-0413
DOI: 10.1055/s-0030-1259645
DOI: 10.1055/s-0030-1259645
Metal-Catalyzed Asymmetric Synthesis and Stereoselective Reactions
© Georg Thieme Verlag
Stuttgart ˙ New York
Enantioselective Mukaiyama Aldol Reactions with Glyoxylates
J.-F. Zhao, B.-H. Tan, T.-P. Loh*
Nanyang Technological University, Singapore
Further Information
Publication History
Publication Date:
18 March 2011 (online)
Significance
The enantioselective aldol reaction is among the most useful and well-developed transformations for the synthesis of chiral materials. Despite this, gaps in asymmetric aldol methodology still exist. The authors present the first example of a general, highly enantioselective Mukaiyama aldol reaction between aryl ketones and glyoxylates. An indium-PyBox complex is used as a chiral Lewis acid to induce asymmetry.