Rhodium(I)-Catalyzed Asymmetric Desymmetrization by Retro-Allylation

M. Waibel; N. Cramer

doi:10.1055/s-0030-1259658

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Synfacts 2011(4): 0393-0393
DOI: 10.1055/s-0030-1259658

Metal-Catalyzed Asymmetric Synthesis and Stereoselective Reactions

Rhodium(I)-Catalyzed Asymmetric Desymmetrization by Retro-Allylation

Contributor(s): Hisashi Yamamoto, Patrick Brady
M. Waibel, N. Cramer*
ETH Zürich, Switzerland

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Publication History

Publication Date:
18 March 2011 (online)

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Significance

A rhodium-catalyzed desymmetrization of meso-norbornenols is described, generating cyclic compounds in high yield and enantioselectivity. Judicious choice of substrate and reaction conditions allows the formation of different products, making this a highly flexible catalytic system.