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Synfacts 2011(4): 0405-0405  
DOI: 10.1055/s-0030-1259660
Metal-Catalyzed Asymmetric Synthesis and Stereoselective Reactions
© Georg Thieme Verlag Stuttgart ˙ New York

Asymmetric Rhodium-Catalyzed Hydrogenation of β-Amino Ketones

Contributor(s): Hisashi Yamamoto, Kimberly Griffin
H. Geng, K. Huang, T. Sun, W. Li, X. Zhang, L. Zhou, W. Wu*, X. Zhang*
Northwest Agriculture & Forestry University, Shaanxi, P. R. of China and Rutgers, The State University of New Jersey, Piscataway, USA
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Publication History

Publication Date:
18 March 2011 (online)

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Significance

Optically pure β-amino ketones are useful synthetic intermediates for biologically active molecules. In this paper, a rhodium-catalyzed hydrogenation yields these products in high conversions and high enantioselectivity.