Ni-Catalyzed Negishi Cross-Coupling of Secondary Alkylzinc Halides

Significance

Herein, a general procedure for a nickel-catalyzed cross-coupling of secondary alkylzinc reagents is reported. The optimized reaction conditions require only low catalyst loads and overcome the problems of isomerization, and β-hydride elimination often encountered in palladium-catalyzed reactions of such secondary alkyl­zinc halides. At the same time, a wide range of functional groups including esters and ­aldehydes is tolerated on both nucleophile and electrophile.