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Synfacts 2011(6): 0663-0663  
DOI: 10.1055/s-0030-1260364
Metal-Mediated Synthesis
© Georg Thieme Verlag Stuttgart ˙ New York

Base-Mediated Biaryl Formation via Benzyne Intermediates

Contributor(s): Paul Knochel, Andreas K. Steib
T. Truong, O. Daugulis*
University of Houston, USA
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Publikationsverlauf

Publikationsdatum:
19. Mai 2011 (online)

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Significance

A new base-promoted intermolecular arylation of (hetero)arenes with aryl chlorides and fluorides has been disclosed. The reaction proceeds via a simultaneous generation of benzyne and an aryl anion, followed by a highly regio­selective biaryl formation.