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Synfacts 2011(9): 1001-1001
DOI: 10.1055/s-0030-1260876
DOI: 10.1055/s-0030-1260876
Metal-Mediated Synthesis
© Georg Thieme Verlag
Stuttgart ˙ New York
Sequential Asymmetric Conjugate Addition and Oxidative Dearomatization
A. Rudolph, P. H. Bos, A. Meetsma, A. J. Minnaard, B. L. Feringa*
University of Groningen, The Netherlands
Further Information
Publication History
Publication Date:
19 August 2011 (online)
Significance
In this work, a sequential asymmetric conjugate addition and oxidative cyclization reaction is reported. In a single transformation, this process allows two carbon-carbon bond formations and leads to a spirocyclic framework with three adjacent stereocenters. Substituents on the substrate or the Grignard reagent are easily varied and allow the introduction of functionalities for further modifications of the scaffold.