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Synfacts 2011(9): 0929-0929  
DOI: 10.1055/s-0030-1260925
Synthesis of Natural Products and Potential Drugs
© Georg Thieme Verlag Stuttgart ˙ New York

Synthesis of (±)-Decursivine and (±)-Serotobenin

Contributor(s): Steven V. Ley, Matthew O’Brien
H. Qin, Z. Xu, Y. Cui, Y. Jia*
Peking University and Lanzhou University, P. R. of China
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Publication History

Publication Date:
19 August 2011 (online)

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Significance

Decursivine is an indole alkaloid isolated from the leaves of Raphidophora decursiva, a flowering plant of the Araceae family which is found in Vietnam. It displays activity against chloroquine resistant strains of malaria. Its structure is very similar to that of the safflower alkaloid serotobenine, also synthesized in this work.