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Synfacts 2011(10): 1087-1087
DOI: 10.1055/s-0030-1261132
DOI: 10.1055/s-0030-1261132
Metal-Catalyzed Asymmetric Synthesis and Stereoselective Reactions
© Georg Thieme Verlag
Stuttgart ˙ New York
Asymmetric Decarboxylative Allylation of Oxindoles
V. Franckevičius, J. D. Cuthbertson, M. Pickworth, D. S. Pugh, R. J. K. Taylor*
University of York, Heslington, UK
Further Information
Publication History
Publication Date:
20 September 2011 (online)
Significance
The authors report on a palladium-catalyzed procedure for the asymmetric allylation of both alkyl- and aryl-substituted oxindoles, creating an all-carbon quaternary stereogenic center in excellent yield and good to excellent enantioselectivity. The general reaction scale for this transformation is 0.15 mmol.