Bazgir A, Hosseini G, Ghahremanzadeh R * Shahid Beheshti University, Tehran and Avicenna Research Institute, Tehran, Iran
Copper Ferrite Nanoparticles: An Efficient and Reusable Nanocatalyst for a Green One-Pot, Three-Component Synthesis of Spirooxindoles in Water.
ACS Comb. Sci. 2013;
15: 530-534
Key words
magnetic nanoparticles - cyclic 1,3-diones - activated acetonitriles - isatins - spirooxindoles
Significance
CuFe2O4 nanoparticles catalyzed the three-component coupling of cyclohexane-1,3-diones, activated acetonitriles and isatins to give the corresponding spirooxindoles (38 examples, 81–97% yield).
Comment
In the synthesis of product A, the catalyst was recovered magnetically and reused four times (1st reuse: 90% yield, 2nd reuse: 89% yield, 3rd reuse: 88% yield, 4th reuse: 80% yield).
