Lewis Acid Catalyzed Intramolecular Ring-Opening of Triazole-Substituted Methylenecyclopropanes: An Approach to 4H-[1,2,3]Triazolopyrazines and 4H-[1,2,3]Triazolo[1,4]diazepines

Abstract

A series of novel methylenecyclopropane-triazoles have been successfully prepared. Their intramolecular nucelophilic cyclizations have been explored in the presence of Yb(NTf₂)₃ catalyst, giving the corresponding triazole containing six- and seven-membered heterocycles in good yields upon heating in toluene.

Key words

triazole - methylenecyclopropanes - Lewis acid - intramolecular cyclization

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