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Synfacts 2015; 11(6): 0641-0642
DOI: 10.1055/s-0034-1380733
DOI: 10.1055/s-0034-1380733
Metal-Mediated Synthesis
Direct Cross-Coupling of Diaryl Zinc Reagents
Further Information
Publication History
Publication Date:
18 May 2015 (online)

Significance
Ingelson and co-workers developed an operationally simple method for the direct C(sp2)–C(sp3) cross-coupling of diarylzinc reagents with benzylic, primary, secondary, and tertiary alkyl halides, leading to the alkylated products in good yields.
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Comment
The reactivity of this cross-coupling reaction was highly solvent dependent and showed excellent functional group tolerance. The products were generally obtained in good yields, and purification by column chromatography was not required.
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