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Synlett 2015; 26(17): 2327-2331
DOI: 10.1055/s-0035-1560054
DOI: 10.1055/s-0035-1560054
synpacts
Transition-Metal-Mediated Synthesis of Trifluoroethyl Aryl Ethers
Further Information
Publication History
Received: 19 June 2015
Accepted after revision: 02 July 2015
Publication Date:
19 August 2015 (online)
Abstract
A series of well-defined copper(I) fluoroalkoxide complexes, [(phen)2Cu][OCH2RF], have been shown to undergo trifluoroethoxylation, pentafluoropropoxylation, and tetrafluoropropoxylation with aryl and heteroaryl bromides to generate the corresponding trifluoroethyl, pentafluoropropyl, and tetrafluoropropyl (hetero)aryl ethers in good to excellent yields. The reaction tolerates a variety of functional groups and demonstrates efficient scalability and practicality.
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