Propargyl-Linked Antifolates Overcome Resistance in S. aureus

Philip Kocienski

doi:10.1055/s-0035-1560253

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Synfacts 2015; 11(10): 1026
DOI: 10.1055/s-0035-1560253

Synthesis of Natural Products and Potential Drugs

Propargyl-Linked Antifolates Overcome Resistance in S. aureus

Contributor(s):

Philip Kocienski

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Publication History

Publication Date:
18 September 2015 (online)

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Key words

antifolate - asymmetric synthesis - conjugate addition - copper catalysis - cinnamates - thioesters - Suzuki–Miyaura cross-coupling - Sonogashira cross-coupling