Li Z, García-Domínguez A, Nevado C * University of Zurich, Switzerland
Pd-Catalyzed Stereoselective Carboperfluoroalkylation of Alkynes.
J. Am. Chem. Soc. 2015;
137: 11610-11613
Key words
palladium - stereoselective reaction - alkynes
Significance
The authors describe a palladium-catalyzed three-component reaction involving terminal alkynes, boronic acids, and perfluoroalkyl iodides, leading to the desired products in a highly regio- and stereocontrolled manner.
Comment
From a mechanistic point of view, the simultaneous addition of both aryl and C
n
F
m
groups across the triple bond in a radical-mediated process is proposed.
