Dehydrogenation Adjacent to Carbonyls Using Palladium–Allyl Intermediates

Aneta Turlik; Yifeng Chen; Timothy R. Newhouse

doi:10.1055/s-0035-1561282

Synlett, Inhaltsverzeichnis

Synlett 2016; 27(03): 331-336
DOI: 10.1055/s-0035-1561282

synpacts

Dehydrogenation Adjacent to Carbonyls Using Palladium–Allyl Intermediates

Aneta Turlik

Department of Chemistry, Yale University, 225 Prospect Street, New Haven, Connecticut 06520-8107, USA eMail: timothy.newhouse@yale.edu

,

Yifeng Chen

Department of Chemistry, Yale University, 225 Prospect Street, New Haven, Connecticut 06520-8107, USA eMail: timothy.newhouse@yale.edu

,

Timothy R. Newhouse*

Department of Chemistry, Yale University, 225 Prospect Street, New Haven, Connecticut 06520-8107, USA eMail: timothy.newhouse@yale.edu

› Institutsangaben

Abstract

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Abstract

Palladium–allyl chemistry has historically been used as a means of allylation of nucleophiles, as developed by Tsuji and Trost in the 1970s. Also during this decade, the Saegusa oxidation, the most prominent palladium-catalyzed dehydrogenation reaction, was developed. This Synpacts article provides a historical overview of dehydrogenation adjacent to carbonyls and our recent contribution to this area: palladium–allyl catalyzed dehydrogenation of nitriles and esters.

Key words

dehydrogenation - oxidation - catalysis - palladium - allyl complexes

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Referenzen

References and Notes

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