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Synlett 2016; 27(19): 2637-2643
DOI: 10.1055/s-0036-1588334
DOI: 10.1055/s-0036-1588334
synpacts
Harnessing Complex Mixtures for Catalyst Discovery
Further Information
Publication History
Received: 22 August 2016
Accepted after revision: 21 September 2016
Publication Date:
11 October 2016 (online)
Abstract
To complement high-throughput experimental approaches to catalyst discovery and optimization, we have employed a simple algorithmic approach to screening and deconvoluting complex mixtures of catalyst components with the goal of rapidly identifying new catalysts and cooperative effects. This Synpacts article highlights how interplay between screening mixtures and mechanistic studies can allow users to rapidly move from initial discovery to rationally developed second-generation catalytic systems.
1 Introduction
2 Application to Lewis and Brønsted Acid Catalysis
3 Application to Transition-Metal Catalysis
4 Conclusion and Perspective
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For undirected screening methods, see:
For reviews describing direct dehydrative substitution of alcohols, see:
For other spectroscopic observations of intermolecular hydrogen-bonding in nitro compounds, see: