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Synlett 2018; 29(05): 542-547
DOI: 10.1055/s-0036-1591913
DOI: 10.1055/s-0036-1591913
synpacts
4-Quinolone N-Oxides as Bacterial Weapons
We gratefully acknowledge funding by the Emmy Noether program of the Deutsche Forschungsgemeinschaft (DFG), an EU FP7 Marie Curie Zukunftskolleg Incoming Fellowship Program (University of Konstanz Grant 291784), the Fonds der Chemischen Industrie (FCI), the Konstanz Research School Chemical Biology (KoRS-CB), and SFB969 (DFG). D.S. was supported by a KoRS-CB PhD fellowship.Further Information
Publication History
Received: 27 October 2017
Accepted after revision: 04 January 2018
Publication Date:
12 February 2018 (online)
Abstract
Various bacterial species are known to produce metabolites of the 4-quinolone N-oxide class. These compounds have antibiotic activities, and are believed to target the respiration of competing microbes by interfering with menaquinone-binding sites in enzymes of the electron-transport chain. Interestingly, even minor structural changes in related N-oxides produced by the same organism can produce a dramatic difference in antibiotic activity, suggesting possible functional specialization.
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