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Synfacts 2018; 14(12): 1309
DOI: 10.1055/s-0037-1611098
DOI: 10.1055/s-0037-1611098
Polymer-Supported Synthesis
Alkyne–Azide Cycloaddition on Water-Soluble Copper NP–Cobaltocene Catalyst
Fu F,
Ciganda R.
*
Wang Q,
Tabey A,
Wang C,
Escobar A,
Martinez-Villacorta AM,
Hernández R,
Moya S,
Fouquet E,
Ruiz J,
Astruc D.
* Université de Bordeaux, Talence, France and Universidad del Pais Vasco and CIC biomaGUNE, Donostia/San Sebastián, Spain
Cobaltocene Reduction of Cu and Ag Salts and Catalytic Behavior of the Nanoparticles Formed.
ACS Catal. 2018;
8: 8100−8106
Cobaltocene Reduction of Cu and Ag Salts and Catalytic Behavior of the Nanoparticles Formed.
ACS Catal. 2018;
8: 8100−8106
Further Information
Publication History
Publication Date:
19 November 2018 (online)
Significance
Water-soluble copper nanoparticles stabilized by a cobalticinium network (CuNPs–CoCp2) were prepared through the reduction of CuSO4·5H2O by cobaltocene (eq. 1). CuNPs–CoCp2 catalyzed the alkyne–azide cycloaddition of terminal alkynes with organic azides in H2O at 35 °C to give the corresponding 1,2,3-triazoles in ≤99% yield (eq. 2; 30 examples).
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Comment
The catalyst was characterized by means of UV-Vis, TEM, and XPS analyses. In the alkyne–azide cycloaddition of phenylacetylene with benzyl azide, the water-soluble catalyst was recovered by decantation and recycled four times with a slight loss of its activity (first run: 99%; fourth run: 86%).
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