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Synfacts 2018; 14(12): 1255
DOI: 10.1055/s-0037-1611312
DOI: 10.1055/s-0037-1611312
Metal-Catalyzed Asymmetric Synthesis and Stereoselective Reactions
Nickel-Catalyzed Enantioselective Reductive Diarylation
Further Information
Publication History
Publication Date:
19 November 2018 (online)

Significance
The authors report a reductive diarylation of alkenes by using a nickel-catalyzed domino process employing two aryl electrophiles. This represents the first report of metal-catalyzed reductive coupling for the synthesis of oxindole scaffolds.
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Comment
Following optimization of the reaction conditions, a broad substrate scope that included aryl bromides and alkenes was observed. An example of an azaoxindole was also demonstrated. The authors consider two possible pathways: One features two oxidative addition steps. The key step of the second pathway is a transmetalation between two nickel(II) species.
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