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Synfacts 2019; 15(02): 0149
DOI: 10.1055/s-0037-1611985
DOI: 10.1055/s-0037-1611985
Metals in Synthesis
Enantioselective α-Functionalization of Ketones
He Z.-T,
Hartwig JF.
* University of California, Berkeley, USA
Enantioselective α-Functionalizations of Ketones via Allylic Substitution of Silyl Enol Ethers.
Nat. Chem. 2018;
DOI: 10.1038/s41557-018-0165-x
Enantioselective α-Functionalizations of Ketones via Allylic Substitution of Silyl Enol Ethers.
Nat. Chem. 2018;
DOI: 10.1038/s41557-018-0165-x
Weitere Informationen
Publikationsverlauf
Publikationsdatum:
18. Januar 2019 (online)
Significance
Hartwig and He developed an efficient and enantioselective method for the α-functionalization of ketones by performing iridium-catalyzed allylic substitutions on silyl enol ethers.
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Comment
The yields and enantio- or diastereoselectivities of this method are exceptionally high, making this protocol extremely useful for the synthesis of enantiomerically pure α-substituted ketones. Additionally, not only N-, but also S-, O-, or C-nucleophiles were applicable to this method.
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