DOI: 10.1055/s-00000131

Synfacts

Issue 02 · Volume 15 · February 2019 DOI: 10.1055/s-009-42311

Synform

A16
Zanda, Matteo: SYNFORM ISSUE 2019/02

Synthesis of Natural Products and Potential Drugs

z0109
All PDFs of this category
0109
Total Synthesis of Saxitoxin and 11-Saxitoxinethanoic Acid
0110
Total Synthesis of (–)-Myrocin G
0111
Synthesis of Grazoprevir
0112
Synthesis of Crizotinib and Etoricoxib
0113
Synthesis of Penicillin V
0114
Synthesis of (+)-Darwinolide
0115
Formal Synthesis of Rhizoxin D
0116
Asymmetric Copper-Catalyzed Hydroamination: Maraviroc
0117
Synthesis of Heterobiaryls by Contractive C–C Coupling
0118
Synthesis of AZD6738
0119
Synthesis of (–)-Mitrephorone A
0120
Total Syntheses of Abies Sesquiterpenoids

Synthesis of Heterocycles

z0121
All PDFs of this category
0121
Photochemical Cyclopropanation of Indoles
0122
Visible-Light-Mediated Minisci C–H Alkylation with Dioxygen as Oxidant
0123
Orthogonal Cross-Coupling of a Trifluoromethylated Chromenone Framework
0124
N-Heterocyclic Carbene Catalyzed Synthesis of Substituted Oxetanes
0125
Photocatalytic γ-Lactam Synthesis by Using Carbon Dioxide Activated Amines
0126
Iron-Catalyzed Synthesis of Fluoroalkylated 2H-Azirines from Alkynes
0127
Synthesis of Trifluoromethylated Pyrroles from Azirines
0128
Stereoselective Synthesis of Tetrahydro-1-benzazepines through [4+3] Annulation
0129
Synthesis of Azepines from 1,2,3-Triazoles and 1,3-Dienes
0130
[3+2]-Cycloaddition Route to Imidazoles and Imidazolines
0131
Annulation of Sulfoximines with Diazo Compounds
0132
Enantioselective Synthesis of 4,9-Dihydrothiopyrano[2,3-b]indol-2(3H)-ones
0133
Carbene-Catalyzed Synthesis of Pyrrolo[3,2-c]quinolines

Synthesis of Materials and Unnatural Products

z0135
All PDFs of this category
0135
1,3a,6a-Triazapentalene Systems: Towards Extended Planar Materials
0136
Tris-[5]helicenes with a Twist
0137
Let Me Tell You a Mild Synthesis of Tellurides
0138
M&M Cascade Polymerization Yields a Palette of Polyenynes
0139
Tunable Indolo[3,2-b]carbazole-Based Boron Complexes
0140
Merging C–H Activation and Radical Chemistry to Construct Polysubstituted Carbohelicenes
0141
Selective Synthesis of Asymmetric Electron-Deficient π-Conjugated Systems
0142
Mix and Match: PAH Synthesis
0143
There’s Node Stopping It
0144
Synthesizing Cross-Conjugated Polymers through Cross-Coupling
0145
A Rainbow of Fluorescent Thieno[3,2-b]pyridine-5(4H)-ones
0146
Efficient Singlet Fission in a Pentacene-Based Nanotube

Metals in Synthesis

z0147
All PDFs of this category
0147
Diastereo- and Enantioselective Conjunctive Cross-Coupling via a Metalate Shift
0148
Rhodium-Catalyzed Cleavage of Aryl–Aryl Bonds
0149
Enantioselective α-Functionalization of Ketones
0150
Lewis Acid Catalyzed Hydroboration of Alkynes and Alkenes
0151
Ruthenium-Catalyzed Enantioselective Transfer Hydrogenation
0152
Regio- and Enantioselective Haloazidation of Allylic Alcohols
0153
1,2-Reduction of Conjugated Ketones: The Luche Reduction
0154
Synthesis of Complex Polycycles through a Samarium(II)-Mediated Folding Cascade
0155
Enantiodivergent Palladium-Catalyzed Cross-Couplings
0156
Catellani Reaction in Tandem with a CMD-Type Process
0157
Ruthenium-Catalyzed Late-Stage Oxygenation
0158
Palladium-Catalyzed Ligand-Controlled Regioselective Acylation
0159
Decarboxylative Heck Coupling via a Cobalt/Photoredox Catalysis
0160
Acetonitrile as CN-Source in Nickel(0)-Catalyzed Cyanation
0161
Palladium/Lewis Acid-Catalyzed Transfer Hydrocyanation of Alkenes and Alkynes
0162
Metal-Catalyzed Oxa[4+2] Cyclization of Quinone Methides with Alkynyl Benzyl Alcohols
0163
Synthesis of Chiral Alkylboronic Esters via Carbosulfenylation
0164
Synthesis of (E)-3-Arylmethyleneisoindolin-1-ones via Palladium(II)/Copper(II) Catalysis
0165
Copper-Catalyzed SN2′′ Substitution of Penta-2,4-Dienyl Phosphates
0166
Defluorinative Alkylation using Redox-Active Esters
0167
Domino Synthesis of α,β-Unsaturated γ-Lactams
0168
Ruthenium-Catalyzed Amide Arylation Using Arylboronic Esters
0169
Palladium-Catalyzed C–H Alkenylation of Arenes Gives Alkenyl Chlorides or Trisubstituted Alkenes
0170
New Access to Trifluoromethylated Ketones
0171
Copper-Catalyzed Remote Arylation
0172
Enantioselective Palladium(II)-Catalyzed Synthesis of 1,2,3,4-Tetrahydro-β-Carbolines
0173
Mild Platinum-Catalyzed Process to Desaturate Lactams, Ketones, and Lactones
0174
Synthesis of Chiral Tetrahydrofurans via Palladium and Squaramide Cooperative Catalysis
0175
Dibenzo[b,d]oxepines by Olefinic C–F Bond Functionalization and Intramolecular Pd–Catalyzed C–H Activation

Polymer-Supported Synthesis

z0177
All PDFs of this category
0177
Hydrosilylation of Alkenes Catalyzed by Platinum on N-Doped Graphene
0178
Alkyne Homocoupling on Carbon Nitride-Supported PdAu Nanocrystals
0179
Reduction of Nitroarenes Catalyzed by a Carbon-Supported Iron Catalyst
0180
Hydrogenation of Cyano and Nitro Compounds by Using Cobalt Nanoparticles on Carbon
0181
Oxidative C–H Chalcogenation of (Het)aryl-Fused Cyclic Amines on Cobalt Oxide Nanoparticles
0182
Nucleophilic Substitution of Naphthols with a Supported Eutectic Solvent Catalyst
0183
Chan–Lam Coupling on a Copper/Covalent Organic Framework Catalyst
0184
Aza-Michael Addition Catalyzed by Encapsulated Magnetite–Hexamethylenetetramine
0185
Selective Hydrogenation of Nitroarenes on Supported Palladium Nanoparticles
0186
Heterogeneous Suzuki Coupling/Asymmetric Transfer Hydrogenation Tandem Reaction
0187
Oxidation of Alcohols on a Supported Schiff Base–Molybdenum(VI) Complex
0188
Formylation of Amines with CO2 by Using a Polymeric N-Heterocyclic Carbene
0189
α-Alkylation of Ketones and Alcohols with a Heterogeneous Zirconium Catalyst

Organo- and Biocatalysis

z0191
All PDFs of this category
0191
Catalytic Asymmetric Mukaiyama Aldol Reaction of Acetaldehyde Enolates
0192
Enantioselective Four-Atom Ring Expansion of Cyclobutanones
0193
Catalytic Asymmetric α-Hydroxylation of Cyclic α-Branched Ketones
0194
Brønsted Acid Catalyzed Diastereoselective [4+3] Cycloaddition
0195
Photoredox-Catalyzed Multicomponent Alkyl Radical Carbonylation
0196
Chiral Sulfides as Catalysts for Asymmetric Electrophilic Olefin Chlorination
0197
A Double Umpolung Reaction to Synthesize β-Amino Amides
0198
Photoredox-Catalyzed Difunctionalization of Olefins with Carbon Dioxide
0199
Enantioselective Photoorganocatalytic Synthesis of 1,4-Dicarbonyl Compounds
0200
The Hajos–Parrish–Eder–Sauer–Wiechert Reaction

Peptide Chemistry

z0201
All PDFs of this category
0201
A Catalytic One-Step Synthesis of Peptide Thioacids
0202
Extension of Native Chemical Ligation
0203
Native Chemical Ligation by Microflow Chemistry
0204
(4-Mercaptophenyl)acetic Acid-Promoted One-Pot Multiple Peptide Ligation
0205
Palladium-Catalyzed C(sp3)–H Activation of Amino Acids and Peptide
0206
Synthesis of Palmitoylated Sonic Hedgehog by Native Chemical Ligation
0207
Nickel-Catalyzed Innate Radical Coupling Reaction
0208
Copper-Catalyzed C(sp3)–H Direct Fluorination of Amino Acids

Flow Chemistry

z0209
All PDFs of this category
0209
Photoredox Arylation of Enol Acetates via Porphyrin Catalysis
0210
C–H Functionalization of Aldehydes with Photolabile Diazo Precursors
0211
Continuous Alcohol Amination by a Hydrogen-Borrowing Protocol
0212
Generation and Cross-Coupling of Organozinc Reagents in Flow
0213
Morita–Baylis–Hillman Reaction under Continuous-Flow Conditions

Erratum

0214
Alwedi, E. M.; Lujan-Montelongo, J. A.; Pitta, B. R.; Chao, A.; Cortés-Mejía, R.; Campo, J. M. D.; Fleming, F. F.: A New Isocyanide Functionalization