Fu J,
Ren Z,
Bacsa J,
Musaev DG,
Davies HM. L.
* Emory University, Atlanta, USA
Desymmetrization of Cyclohexanes by Site- and Stereoselective C–H Functionalization.
Nature 2018;
564: 395-399
Key words
desymmetrization - C–H activation - stereoselectivity
Significance
The authors report a site- and stereoselective desymmetrization of cyclohexanes via a rhodium-complex-catalyzed C–H functionalization.
Comment
The method does not require any directing group and can be applied to unactivated C–H bonds, which presents a limitation for similar methods.
