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Synfacts 2019; 15(04): 0375
DOI: 10.1055/s-0037-1612309
Metals in Synthesis
© Georg Thieme Verlag Stuttgart · New York

Cyclohexane Desymmetrization via Rhodium-Catalyzed C–H Activation

Contributor(s):
Paul Knochel
,
Simon Graßl
Fu J, Ren Z, Bacsa J, Musaev DG, Davies HM. L. * Emory University, Atlanta, USA
Desymmetrization of Cyclohexanes by Site- and Stereoselective C–H Functionalization.

Nature 2018;
564: 395-399
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Further Information

Publication History

Publication Date:
19 March 2019 (online)

 
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Key words

desymmetrization - C–H activation - stereoselectivity

Significance

The authors report a site- and stereoselective desymmetrization of cyclohexanes via a rhodium-complex-catalyzed C–H functionalization.


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Comment

The method does not require any directing group and can be applied to unactivated C–H bonds, which presents a limitation for similar methods.


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