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Synfacts 2019; 15(05): 0491
DOI: 10.1055/s-0037-1612481
DOI: 10.1055/s-0037-1612481
Synthesis of Materials and Unnatural Products
Harp on HaRP
Further Information
Publication History
Publication Date:
15 April 2019 (online)
Significance
The development of new methods for chain-growth polymerization enables the investigation of novel monomer and polymer architectures with precise control over molecular weight. In this study, Gutekunst et al. develop the Halide-Rebound Polymerization (HaRP), which takes advantage of the increased nucleophilicity of twisted amide 1.
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Comment
By using an alkyl iodide as an initiator, the resulting chain end is neither air- and moisture-sensitive. This enables the facile synthesis of block co-polymers, as well as quantitative end-group functionalization. Polymer structure was confirmed by both model studies and MALDI-ToF analysis.
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