DOI: 10.1055/s-00000131

Synfacts

Issue 05 · Volume 2019 · May 2019 DOI: 10.1055/s-009-42901

Synform

A63
Zanda, Matteo: SYNFORM ISSUE 2019/05

Synthesis of Natural Products and Potential Drugs

z0463
All PDFs of this category
0463
Total Synthesis of (–)-Vinigrol
0464
Formal Synthesis of (±)-Morphine
0465
Synthesis of BMS-741672
0466
Synthesis of (+)-Strychnine
0467
Total Synthesis of (±)-Methyl Homosecodaphniphyllate
0468
Synthesis of GDC-0339
0469
Synthesis of a Dipeptidyl Peptidase-4 Inhibitor
0470
Synthesis of 1′,2′-Methano-2′,3′-dideoxynucleosides
0471
Total Synthesis of (–)-Azamerone
0472
Synthesis of an EGFR T790M Inhibitor
0473
Synthesis of Atropurpuran
0474
Synthesis of (–)-Cerorubenic Acid-III

Synthesis of Heterocycles

z0475
All PDFs of this category
0475
Vanadium-Catalyzed Pyrrole Synthesis
0476
Synthesis of Pyrimidine Nucleobases under Prebiotic Conditions
0477
Transannular C–H Arylation of the Azabicyclo[3.1.0]hexane Core
0478
Catalytic Enantioselective Synthesis of 2-Pyrazolines
0479
Gold-Catalyzed Decarboxylative Benzylation of Indoles
0480
Quinolines by Hydride Abstraction Induced Electrocyclization
0481
1H-Pyrrolo[2,3-d]carbazoles by Brønsted Acid Catalyzed Cyclization of Ynamides
0482
Palladium-Catalyzed Synthesis of Polycyclics from Aryl Iodides and Alkynes
0483
Enantioselective Aza-Heck Approach to N-Heterocycles
0484
Palladium-Catalyzed Synthesis of Dihydropyrido-[1,2-a]indolones
0485
Palladium-Catalyzed Asymmetric Allylation of α-Amidopyridinium Salts
0486
Benzoxazoles and Benzoxazines by Intramolecular Aryl Azide Insertion
0487
Nickel-Catalyzed Michael Reaction of Malonates and Nitroalkenes
0488
Minisci Reaction with Organotrifluoroborates: Merging Photo- and Electrochemistry

Synthesis of Materials and Unnatural Products

z0489
All PDFs of this category
0489
It Takes Alkynes
0490
A (Rhoda)Electrifying Synthesis of Substituted PAHs
0491
Harp on HaRP
0492
Honey, I Shrunk the Polymers
0493
Rhodium-Catalyzed Synthesis of Blue-Emitters
0494
Controllable C–H Cyclization of N-Alkyl-N-arylanthranilic Acids
0495
PhosWhoa: An Intriguing Synthesis of Substituted Phospholones
0496
Chan–Lam–Evans Coupling is Now Available on Carbon Nanotubes
0497
Breaking the Habit: Synthesis of Unsymmetrically Substituted Tetravinylethylenes
0498
Turning Nanohoops On
0499
One for the Books: Largest Prepared Perphenylacene
0500
Full to the Brim: Rim-Substituted Corannulenes as Non-fullerene Electron Acceptors

Metals in Synthesis

z0501
All PDFs of this category
0501
Ag+/Proton Relay Catalysis for Stereoselective Synthesis of Spiro-2-oxabicyclo[2.2.2]octanes
0502
Synthesis of 4-Substituted Isoxazolines via a Gold-Catalyzed Skeletal Rearrangement
0503
Controlling Facial Selectivity Towards Carbocations via a Docking Strategy
0504
Copper-Catalyzed C–H Carbamoyloxylation of Aryl Carboxamides
0505
Palladium-Catalyzed Enantioselective Aminotrifluoromethoxylation of Alkenes
0506
Enantioselective Synthesis of α-Chiral Silanes
0507
Nickel-Catalyzed Hydroarylation
0508
Copper-Catalyzed Enantioselective Allylation Using Allene
0509
Enantioselective Copper-Catalyzed Synthesis of α-Arylpyrrolidines
0510
Nickel-Catalyzed Asymmetric Synthesis of Organosilanes
0511
Deaminative Nickel-Catalyzed Alkyl–Alkyl Cross-Couplings
0512
Iridium-Catalyzed ‘Chain-Walking’/Cope Rearrangement
0513
Palladium-Catalyzed Dual Annulation: Towards the Norneocryptolepine Core
0514
Nickel-Catalyzed N-Arylations via Nitrogen Radicals
0515
Photoredox-Catalyzed α-Alkylation of Amines
0516
Asymmetric Diarylation of Vinylarenes
0517
The Jacobsen Epoxidation
0518
Nickel-Catalyzed Electrochemical Thiolation
0519
Photochemical Giese Addition to Olefins
0520
Catalytic Radical Difluoromethoxylation
0521
Rhodium-Catalyzed Reverse Hydroboration
0522
Palladium-Catalyzed Synthesis of Difluoromethylated Esters
0523
The Takai Olefination: Simple Access to E-Alkenyl Halides
0524
Copper-Catalyzed C–H Oxidative Radical Functionalization of Olefins
0525
Synthesis of Chiral Pyrazoles: Dynamic Kinetic Resolution of Allenes
0526
Selective C–N Bond Cleaving Kumada Cross-Coupling
0527
Heck Coupling of Cyclopropanated Heterocycles
0528
Dinickel-Catalyzed [4+1] Cycloadditions
0529
ortho-Borylation of Arylphosphines

Polymer-Supported Synthesis

z0531
All PDFs of this category
0531
Synthesis of N-Alkylcyclohexylamines on Supported Rh/Pt Nanoparticles
0532
Cobalt-Catalyzed Regio- and Stereoselective Hydrosilylation of Alkynes
0533
Dehydrative Allylation of Amines with Allyl Alcohol on Supported Molybdenum Oxide
0534
Cyclization of Propargylic Alcohols with CO2 on a Cu4I4 Metal–Organic Framework
0535
Palladium-Catalyzed Coupling of 2-Hydroxy-1,4-naphthoquinones with Olefins
0536
Pd-Catalyzed Cyclization of 2-Iodoanilines with Alkynes and Oxalic Acid
0537
Hydrodeoxygenation of Carboxylic Acids on N-Doped-Carbon-Supported Iron
0538
Synthesis of 1H-Tetrazoles with a Resin-Supported Tin Catalyst
0539
Dehydrogenation of Amines and Transamination on Pd-Doped Hydrotalcites
0540
Cycloaddition of CO2 to Epoxides with an Al(III)–Salen Molecular Cage
0541
Oxidative Heck Reaction on a Porous-Polymer-Supported Palladium Catalyst
0542
Hydrogenation of Ketones on Silver Nanoparticles

Organo- and Biocatalysis

z0543
All PDFs of this category
0543
N-Heterocyclic Carbene Catalyzed Alkylation of Aromatic Aldehydes
0544
Acid-Catalyzed Intramolecular Hydroindolation of cis-Methindolylstyrenes
0545
Hydrogen-Bonding Phase-Transfer Catalysis toward β-Fluoroamines
0546
Chiral Brønsted Acid Catalyzed Asymmetric Oxidation of Sulfenamides
0547
Enantioselective Aminocatalytic Heterocycloadditions
0548
Asymmetric Organocatalytic Oxidative Coupling of Indoles with Aldehydes
0549
Stereospecific Biocatalytic Friedel–Crafts Alkylation of Resorcinols
0550
Asymmetric Countercation Directed Catalysis of an SN2X Reaction
0551
Enzymatic Carboxylation of 2-Furoic Acid to 2,5-Furandicarboxylic Acid
0552
The Asymmetric Nazarov Cyclization of Simple Divinyl Ketones
0553
Asymmetric Countercation Directed Catalytic Resolution of BINOLs
0554
Cinchona Alkaloids in Organic Catalysis

Chemistry in Medicine and Biology

z0555
All PDFs of this category
0555
Four New DNA Building Blocks
0556
Organelle-Targeted Membrane Tension Probes
0557
Bioactive Analogues of TAN-2483B
0558
A Manganese-Based Contrast Agent for Imaging Calcium Ions
0559
Functionalization of Palladium Oxidative Addition Complexes Derived From Pharmaceuticals
0560
Targeting the RAS–SOS1 Interaction
0561
Ethynylphosphonamidate-Cysteine Bioconjugation
0562
A High Affinity Fluorescent Sensor for Norepinephrine
0563
Ring-Closing Metathesis in the Synthesis of Simeprevir
0564
Antimalarial 1,2,4-Triazine Dimers
0565
New Methods to Access DNA-Encoded Libraries (DELs)

Peptide Chemistry

z0567
All PDFs of this category
0567
Pd-Catalyzed Oxazoloisoindolinone Synthesis from N-Benzoyl-α-Amino Acids
0568
C-Terminal Elongation of Dipeptide Isopropenyl Esters
0569
Efficient Macrocyclization of Small Peptides
0570
Cleavage of Fmoc Groups with Sodium Hydroxide in 2-Methyltetrahydrofuran–Methanol
0571
Copper-Catalyzed Multicomponent Synthesis of Quaternary α-Amino Esters
0572
Thiourea-Catalyzed Asymmetric Mannich Reaction
0573
Synthesis of Peptides by Using Recombinant Proteins
0574
Chemoselective Ligation by Using an Adipic Acid Dihydrazide Crosslinker

Flow Chemistry

z0575
All PDFs of this category
0575
Continuous-Flow, Michaelis−Arbuzov Rearrangement
0576
DFT Guides the Optimization of Photosensitized [2+2] Cycloadditions in Flow
0577
Synthesis of Ketones from Organolithium Reagents in Continuous Flow
0578
Flow Synthesis of Ciprofloxacin
0579
Flow Synthesis of Lomustine