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Synfacts 2019; 15(05): 0555
DOI: 10.1055/s-0037-1612507
DOI: 10.1055/s-0037-1612507
Chemistry in Medicine and Biology
Four New DNA Building Blocks
Hoshika S,
Leal NA,
Kim M.-J,
Kim M.-S,
Karalkar NB,
Kim H.-J,
Bates AM,
Watkins NE. J,
SantaLucia HA,
Meyer AJ,
DasGupta S,
Piccirilli JA,
Ellington AD,
SantaLucia JJ,
Georgiadis MM,
Benner SA.
* Firebird Biomolecular Sciences LLC and Foundation for Applied Molecular Evolution, Alachua, Indiana University School of Medicine, University of Chicago University of Texas, Austin, and DNA Software Inc., Ann Arbor, USA
Hachimoji DNA and RNA: A Genetic System with Eight Building Blocks.
Science 2019;
363: 884-887
Hachimoji DNA and RNA: A Genetic System with Eight Building Blocks.
Science 2019;
363: 884-887
Further Information
Publication History
Publication Date:
15 April 2019 (online)
Significance
An artificial genetic system, hachimoji DNA (from Japanese ‘eight letters’) has been obtained using novel nucleotides P, B, Z, and S in combination with standard nucleotides. Hachimoji DNA builds structures with properties similar to those of natural DNA and can be transcribed into hachimoji RNA.
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Comment
The synthesis of hachimoji DNA involves the novel purines P and B and the pyrimidines Z and S analogues. The representative synthesis of dS phosphoramidite was reported previously by Benner and co-workers in Bioorg. Med. Chem. 2009, 17, 3728.
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