RSS-Feed abonnieren
DOI: 10.1055/s-0037-1612544
Iron-Catalyzed Alkenylation of Organomagnesium Reagents
Publikationsverlauf
Publikationsdatum:
20. Mai 2019 (online)

Significance
In 1998, Cahiez and Avedissian reported a general method for the iron-catalyzed cross-coupling between alkenyl halides (halide = Cl, Br, or I) and Grignard reagents in high yields and excellent diastereoselectivities (>99:1).
Comment
The approach significantly improved the cross-coupling between alkenyl halides and Grignard reagents using Fe(acac)3 as catalyst. Additionally, it was found that the use of a polar co-solvent such as NMP was crucial for the cross-coupling to proceed in excellent yields. Furthermore, functional groups such as ketones were tolerated for the first time in these cross-coupling reactions (see Review below).
Review
C. Bolm, J. Legros, J. Le Paih, L. Zani Chem. Rev. 2004, 104, 6217–6254.
