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Synfacts 2019; 15(06): 0681
DOI: 10.1055/s-0037-1612573
Chemistry in Medicine and Biology
© Georg Thieme Verlag Stuttgart · New York

Development of Fluorescent Ca2+ Sensors

Contributor(s):
Dirk Trauner
,
Johannes Morstein
Grynkiewicz G, Poenie M, Tsien RY. * University of California, Berkeley, USA
A New Generation of Ca2+ Indicators with Greatly Improved Fluorescence Properties.

J. Biol. Chem. 1985;
260: 3440-3450
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Further Information

Publication History

Publication Date:
20 May 2019 (online)

 
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Key words

fluorophores - probes - calcium cation

Significance

Calcium sensors such as indo 1 are routinely used in biological research to monitor calcium mobilization. Calcium can be mobilized from various subcellular compartments (e.g., ER, lysosomes, or mitochondria) and via different mechanisms (e.g., activation of Gq-coupled GPCRs or ion channels).


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Comment

Indo 1 and five other fluorescent calcium indicators were synthesized through related synthetic routes. They can be easily converted into AM-Dyes. The general synthesis of AM-Dyes was published in Nature 1981, 290, 527–528.


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