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Thromb Haemost 1999; 81(06): 957-960
DOI: 10.1055/s-0037-1614606
Letters to the Editor
Schattauer GmbH

Effect of Clopidogrel on Thrombin Generation in Platelet-Rich Plasma in the Rat

J.-P. Hérault
1   From the Haemobiology Research Department, Sanofi Recherche, Toulouse, France
,
F. Dol
1   From the Haemobiology Research Department, Sanofi Recherche, Toulouse, France
,
C. Gaich
1   From the Haemobiology Research Department, Sanofi Recherche, Toulouse, France
,
A. Bernat
1   From the Haemobiology Research Department, Sanofi Recherche, Toulouse, France
,
J.-M. Herbert
› Author Affiliations
Further Information

Publication History

Received 22 October 1998

Accepted after resubmission 08 March 1999

Publication Date:
09 December 2017 (online)

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Summary

Clopidogrel (25 mg/kg, p.o.), a potent and selective inhibitor of ADP-induced platelet aggregation, significantly inhibited, in the presence of platelets, ex vivo thrombin generation triggered by low concentrations of tissue factor. Clopidogrel reduced the area under the curve (23%, p <0.05) and the thrombin peak concentration (35%, p <0.05) but did not affect the lag phase of thrombin generation. Under the same experimental conditions, heparin (100 μg/ml) inhibited thrombin generation mostly by delaying and by reducing the burst of thrombin. In a stasis-induced venous thrombosis model in rats under low thrombogenic challenge, clopidogrel inhibited thrombus formation (ED50 = 7.9 ± 1.5 mg/kg, p.o. – n = 10), confirming the existence of a close relationship between platelet activation and thrombin generation leading to blood coagulation and venous thrombosis.

 

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