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Synfacts 2020; 16(12): 1495
DOI: 10.1055/s-0040-1706596
Peptide Chemistry

Synthesis of Reactive Amino Acid Esters by Using Amino Acid Chlorides in a Biphasic System

Contributor(s):
Hisashi Yamamoto
,
An Wu
Suresh Babu VV, *, Ananda K, Mathad RI. Bangalore University, India
Synthesis of Pentafluorophenyl, 2,4,5-Trichlorophenyl and Pentachlorophenyl Esters of Fmoc-Amino Acids Using Fmoc-Amino Acid Chlorides as Intermediates.

Lett. Pept. Sci. 2000;
7: 239-242
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Key words

amino acid chlorides - phenols - amino acid esters - biphasic system

Significance

Reactive amino acid phenyl esters have been used in peptide synthesis. The authors developed a method where amino acid chlorides and inorganic base are used to prepare reactive amino acid esters in a two-phase system.


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Comment

With the inorganic base NaHCO3, various reactive amino acid phenyl esters can be synthesized without using classical peptide-coupling reagents. The yields of the reactions were moderate to good.


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Publication History

Article published online:
17 November 2020

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