DOI: 10.1055/s-00000131

Synfacts

Issue 12 · Volume 16 · December 2020 DOI: 10.1055/s-010-49806

Synform

A171
Zanda, Matteo: SYNFORM ISSUE 2020/12

Synthesis of Natural Products and Potential Drugs

z1383
All PDFs of this category
1383
Total Synthesis of (±)-Tronocarpine
1384
Synthesis of a Remdesivir Intermediate
1385
Synthesis of Olodanrigan
1386
Synthesis of (±)-Liangshanone
1387
Total Synthesis of (+)-Formosalides A and B
1388
Synthesis of Ritobegron Ethyl Hydrochloride
1389
Synthesis of MK-5204
1390
Enantioselective Synthesis of (–)-Deoxoapodine
1391
Synthesis of (–)-Flueggenines D and I
1392
Synthesis of BMS-986235/LAR-1219
1393
Asymmetric Synthesis of an hNK1 Inhibitor
1394
Synthesis of A-1331852
1395
Formal Synthesis of (–)-Quinine
1396
Total Synthesis of (+)-Jolantidine

Synthesis of Heterocycles

z1397
All PDFs of this category
1397
Iodine/Trifluoroacetic Acid-Assisted Multicomponent Synthesis of 4(3H)-Quinazolinones
1398
Electrocatalytic Decarboxylative Synthesis of 1,3,4-Oxadiazoles
1399
Tuning Redox Properties of Bistetronates through Spacer Selection
1400
Stereoselective Synthesis of Cyclopenta[c]pyrazoles by an Interrupted Ohira–Bestmann Reaction
1401
Hypervalent Iodine(III)-Mediated Synthesis of Spirooxazolines
1402
Regioselective C–H Arylation of Quinolone Derivatives
1403
Synthesis of Oxygen-Rich Polycyclic Scaffolds
1404
[4+1]-Spiroannulation of Bromophenols with α,β-Unsaturated Imines: Synthesis of Azaspirocycles
1405
Cobalt-Catalyzed Synthesis of Pyrroles from Nitroarenes
1406
Synthesis of 1,3,4,11-Tetrahydrooxocino[3,4-b]indoles
1407
Synthesis of 1,2,3-Benzothiazaphosphole 1,1-Dioxides
1408
Diverse Syntheses of Furochromone-Based Antimicrobial Agents
1409
Asymmetric Synthesis of Spiro-Benzofurans and Fused Benzopyrans

Synthesis of Materials and Unnatural Products

z1411
All PDFs of this category
1411
Peeling Carbon Onions
1412
Mechanochemistry at its Best! An Improved Synthesis of Corannulene-Based Nanographene
1413
Extended Porphyrins Containing One or Two Naphthalimide Subunits
1414
Dioxa[6]helicenes, Expedited
1415
Naphthalene Diimides with Fused Sulfur Heterocycles
1416
Metal-Free Synthesis of 7-Hydroxy-6H-naphtho[2,3-c]coumarins
1417
In with the Old, Out with the New: Homologation of Fischer Indolization to Synthesize Quinolines
1418
Pick Your Own (Regioselective) Addition
1419
Expanding the Library of Cationic [5]Helicenes
1420
Working the Strain Off Cyclooctadiene-Diynes to Scale-Up Cyclic Polymer Synthesis
1421
Synthesis of a Condensed Phenoxazine Dimer and Its Radical Cation Salt
1422
Unsymmetrical Diarylation of Perylene Diimides

Metals in Synthesis

z1423
All PDFs of this category
1423
Deoxygenation and Borylation of Ketones via Rhodium Catalysis
1424
Regiodivergent Hydrofunctionalization of α,β-Unsaturated Carboxylic Acids
1425
Asymmetric Synthesis of Amino Alcohols Using a Catalytically Formed Chiral Auxiliary
1426
Direct Chlorination of Acrylamide Derivatives
1427
α-Alkylation of Unprotected Alicyclic Amines
1428
Manganese-PN3 Catalyst Generating Tetrahydro-quinolines via a Hydrogen-Borrowing Mechanism
1429
Aza-Paternò–Büchi Reaction for Synthesis of Fused Azetidines
1430
Ruthenium-Catalyzed C(sp3)–H Bond Oxygenation of N-Benzoyloxycarbamates
1431
Air-Stable Palladium(I) Dimer for Olefin Migration and C–C Coupling
1432
Ligand-Free Regioselective Iron-Catalyzed Hydroboration of Terminal Alkenes
1433
Remote Catalytic Reductive C–H Carboxylation of Arenes with CO2 via 1,4-Nickel Migration
1434
Copper-Catalyzed C–N Cross-Coupling of Sterically Hindered Aryl Halides and Amines
1435
Iron-Catalyzed Preparation of Sulfinamides from Thiols
1436
Rhodium-Catalyzed Preparation of Pyrrolidines from Primary Amines
1437
Iridium-Catalyzed Asymmetric Synthesis of 1,2-Fluorohydrins
1438
Direct and Selective Palladium-Catalyzed Carbonylation of Allylic Alcohols
1439
Accessing (Multi)Fluorinated Piperidines Using Heterogeneous Hydrogenation
1440
Enantioselective [4+1] Cycloaddition by a Dinuclear Nickel Catalyst
1441
Nickel-Catalyzed Enantioselective Migratory Hydrocyanation of Nonconjugated Dienes
1442
Enantioconvergent Coupling of Racemic Alkyl Bromides with Azole C–H Bonds
1443
Titanium-Catalyzed Deoxygenative Radical C−C Bond-Forming Reaction of Tertiary Alcohols
1444
Palladium-Catalyzed Synthesis of Coumarins with β-Borylacrylates
1445
Migratory Cross-Coupling of Alkyl Halides via Nickel Catalysis
1446
α-C–H Alkynylation of N‑Alkylamines by Copper/Lewis Acid Catalysis
1447
para-Selective Arylation via Norbornene Relay Palladation
1448
Electrophotocatalytic Azidation of C(sp3)–H Bonds
1449
Nickel-Catalyzed Defluorination of Aromatic Amides
1450
Regioselective Markovnikov Cobalt-Catalyzed Hydroboration of Alkynes
1451
Cross-Coupling of Organosilanes with Organic Halides Mediated by Palladium Catalyst and TASF

Polymer-Supported Synthesis

z1453
All PDFs of this category
1453
One-Pot Two-Step Catalytic Asymmetric Michael Addition/Hydrogenation
1454
Photocatalytic Pinacol Coupling of Benzaldehydes Using ZnIn2S4 Nanosheets
1455
Heterogeneous Ruthenium/Tungsten-Catalyzed One-Pot Reductive Amination of Carboxylic Acids
1456
Indenoquinoxalines Synthesis on Chitosan-Modified MnFe2O4 Magnetic Nanoparticles
1457
Hydrogenation of N-Hetarenes on Silica-Supported Cobalt/Carboxylic Acid Nanoparticles
1458
Synthesis of Benzimidazoles and Benzothiazoles on Pt NPs Supported on a Sulfur-Containing Dendrimer
1459
Decarboxylative Alkynylation of Carboxylic Acid Promoted by Graphitic Carbon Nitride
1460
Ruthenium/Magnesium Oxide-Catalyzed Direct Amination of Alcohols with Ammonia
1461
Gold-Catalyzed Carboxylation and Hydration of Terminal Aralkynes
1462
Aromatic Hydrogenation under Ambient Conditions

Organo- and Biocatalysis

z1463
All PDFs of this category
1463
A Selenium-Catalyzed Oxidative Allylic Sulfonamidation
1464
Organic Photocatalyzed Radical–Radical Cross-Coupling toward Heteroarylamines
1465
Organophotoredox-Catalyzed Reductive Cleavage of Oxidized Lignin Model Substrates
1466
Enantioselective Acylation of 3-Hydroxyphthalides by Pyrrolomidazole-Catalyzed Dynamic Kinetic Resolution
1467
Radical-Cation-Accelerated Nucleophilic Aromatic Substitution of Electron-Rich Aryl Fluorides
1468
Tandem Catalytic Dynamic Kinetic Resolutions toward Two-Axis Atropisomers
1469
Ene-Reductase Permits Asymmetric Reductive Cyclization via Photoenzymatic Generation of Radicals
1470
Chiral Confinement Permits Enantiocontrolled Reactions To Proceed via Nonclassical Carbocations
1471
P(III)/P(V)-Catalyzed Reductive Methylamination of Arylboronic Acids and Esters with Nitromethane
1472
Asymmetric 1,4-Reduction of 2-Vinylazaarenes with Pinacolborane
1473
Carbocationic Rearrangements: Aryl-Iodide-Catalyzed Enantioselective Synthesis of 1,3-Difluorides

Chemistry in Medicine and Biology

z1475
All PDFs of this category
1475
Next Generation Vancomycin Total Synthesis
1476
Introducing a Chiral Tricycle that Renders a Selective JAK Inhibitor
1477
Overcoming Vat Resistance with de Novo Synthesis of New Group A Streptogramin Analogues
1478
Radical Difluorination
1479
Local Labeling of Lipids
1480
Diversity-Oriented Synthesis of Acylphloroglucinol Scaffolds
1481
First Simultaneous Removal of SIRT2 Deacetylase and Defatty-Acylase Activities with PROTACs
1482
A New Generation of Molecular Imaging Probes for Carbon Monoxide Detection in Living Systems
1483
Optical Control of the Peroxisome Proliferator-Activated Receptor γ (PPARγ)
1484
Stereoselective Covalent Inhibitors of T-Cell Activation
1485
Progesterone from Mexican Yams
1486
Sulfuramidimidoyl Fluorides as SuFEx Electrophiles for the Inverse Drug Discovery of Covalent Drugs

Peptide Chemistry

z1487
All PDFs of this category
1487
Visible-Light-Mediated Functionalization of Cysteine Derivatives and Cysteine-Containing Peptides
1488
Synthesis of Hexahydropyrrolo[3,4-b]pyrrole-Fused Quinolines from α-Amino Acid Methyl Esters
1489
Iridium-Catalyzed Synthesis of Quaternary α- through ε-Amino Acid Derivatives
1490
Palladium-Catalyzed Synthesis of Azatryptophan Analogues
1491
Copper-Catalyzed Synthesis of Peptide-Containing Macrocyclic Alkynyl Sulfides
1492
Photoredox-Catalyzed Synthesis of γ-Amino Acids from Styrenes, Amines, and CO2
1493
Three-Component Reaction Toward γ-Carbonyl-α-Amino Acids
1494
Modification of the N-Terminus of Peptides
1495
Synthesis of Reactive Amino Acid Esters by Using Amino Acid Chlorides in a Biphasic System

Flow Chemistry

z1497
All PDFs of this category
1497
Rhodium-Catalyzed Hydrogenation of Enamides and α-or β-Dehydroamino Acids
1498
Asymmetric Conjugate Addition–Oxidation Sequence in Flow Generating GABA Analogues
1499
Preparation and Use of Halomethyl Grignard Reagents in Continuous Flow
1500
Progress toward Fully Automated Chemical Synthesis