Tobiesen HN,
Leth LA,
Iversen MV,
Næsborg L,
Bertelsen S,
Jørgensen KA.
*
Aarhus University, Denmark
Stereoselective Oxidative Bioconjugation of Amino Acids and Oligopeptides to Aldehydes.
Angew. Chem. Int. Ed. 2020;
DOI:
10.1002/anie.202008513
Key words
metal-free - organocatalysis - bioconjugation - amino acids - aldehydes - asymmetric reaction
Significance
The synthesis of modified amino acids is significant in the pharmaceutical industry and in medicinal chemistry. The authors used a metal-free oxidative bioconjugation method to couple amino acids and aldehydes.
Comment
Various amino acid esters are synthesized from amino acids and α-branched aldehydes. The yields of the reactions were moderate to good, and the stereoselectivities were good.
