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Synfacts 2020; 16(10): 1237
DOI: 10.1055/s-0040-1707360
Peptide Chemistry

Coupling of Amino Acids and α-Branched Aldehydes

Contributor(s):
Hisashi Yamamoto
,
An Wu
Tobiesen HN, Leth LA, Iversen MV, Næsborg L, Bertelsen S, Jørgensen KA. * Aarhus University, Denmark
Stereoselective Oxidative Bioconjugation of Amino Acids and Oligopeptides to Aldehydes.

Angew. Chem. Int. Ed. 2020;
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Key words

metal-free - organocatalysis - bioconjugation - amino acids - aldehydes - asymmetric reaction

Significance

The synthesis of modified amino acids is significant in the pharmaceutical industry and in medicinal chemistry. The authors used a metal-free oxidative bioconjugation method to couple amino acids and aldehydes.


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Comment

Various amino acid esters are synthesized from amino acids and α-branched aldehydes. The yields of the reactions were moderate to good, and the stereoselectivities were good.


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Publication History

Article published online:
17 September 2020

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