DOI: 10.1055/s-00000131

Synfacts

Issue 10 · Volume 16 · October 2020 DOI: 10.1055/s-010-49454

Synform

A138
Zanda, Matteo: SYNFORM ISSUE 2020/10

Synthesis of Natural Products and Potential Drugs

z1133
All PDFs of this category
1133
Synthesis of (±)-Cryptotrione
1134
Asymmetric Synthsis of (S)-Verapamil
1135
Synthesis of 4-(Aminomethyl)quinolin-2(1H)-ones
1136
Formal Synthesis of (±)-Haouamine A
1137
Synthesis of β-Lactamase Inhibitor QPX7728
1138
Total Synthesis of (+)-Tagetitoxin
1139
Synthesis of (+)-Rubellin C
1140
Synthesis of a Glucokinase Activator
1141
Synthesis of β-Lactamase Inhibitor IID572
1142
Total Synthesis of Bufospirostenin A
1143
Total Synthesis of (–)-Arborisidine
1144
Synthesis of BMS-986260
1145
Synthesis of AB928
1146
Synthesis of (±)-Hibiscone C

Synthesis of Heterocycles

z1147
All PDFs of this category
1147
Modular Syntheses of 5- and 6-Azaindoles
1148
Modular Synthesis of 2,5-Diaryltetrazoles
1149
Synthesis of C2-Substituted Imidazolones
1150
Nickel-Catalyzed Enantioselective Synthesis of 3,3-Disubstituted Oxindoles
1151
Cine-Substitutions of Five-Membered Hetarenes via Sulfonium Salts
1152
Synthesis of Indoles through C–C and C–N Bond Formation of Aliphatic Amines and Nitrosoarenes
1153
One-Pot Synthesis of Polycyclic Indolones by Photocatalytic Annulation of Redox-Active Esters
1154
Bismuth(III)-Catalyzed Synthesis of 2-(Fluoroalkyl)imidazole-5-carbaldehydes
1155
A Sequential C–H Activation–Annulation Route to Fused Phthalimides
1156
Copper-Catalyzed Three-Component Synthesis of γ-Lactams
1157
Synthesis of Chiral γ-Lactams through Pd(II)-Catalyzed Cascade Alkenylation/Aza-Wacker Cyclization
1158
Indium-Catalyzed Synthesis of 1,2-Dihydroquinolines through Rearrangement of Oxetanes

Synthesis of Materials and Unnatural Products

z1159
All PDFs of this category
1159
So Long, Sulfur!
1160
About to Take Off? A Flapping Peryleneimide Fluorophore with Tunable Fluorogenic Properties
1161
Handedness Lends a Hand: Chirality-Assisted Synthesis of Enantioenriched Triptycene Derivatives
1162
Two Reaction Conditions, One New Pentacyclic Pyrylium Emitter
1163
Multitasking Material: A Porous 3D Organic Polymer with High Surface-Area and Semiconducting Properties
1164
But Wait, There’s More to Cyclo[18]carbon!
1165
Expanding the Circulene Family
1166
Belt-Like Macrocycles as Molecular Containers
1167
Two New Phenalenannulation Designs
1168
A New Path to 9,10-Dihydroacridines and Nitrogen-Doped Polyacenes
1169
Bright Boron Binders: Highly Fluorescent Acylated ‘BDan’ Compounds
1170
All Nitriles Lead to Imidazoles

Metals in Synthesis

z1171
All PDFs of this category
1171
Rhodium-Catalyzed Enantioselective Diarylcarbene Insertion into Si–H Bonds
1172
Radical Relayed Reductive Coupling for Double Functionalization of Vinylamides and -boranes
1173
Palladium-Catalyzed Cross-Couplings of Alkyllithiums with Aryl Chlorides
1174
Hydroamination of Styrenes under Air and Moisture
1175
Copper-Catalyzed Csp–S Couplings
1176
Nickel-Catalyzed Asymmetric Synthesis of Methylenecyclopropanes
1177
Enantioselective Hydroxylation of Benzylic C(sp3)–H Bonds Catalyzed by a Chiral Aryl Iodide and Copper
1178
Synthesis of Bicyclic Lactones by Palladium-Catalyzed Carbonylative Cyclopropanol Ring-Opening
1179
Iron-Catalyzed Three-Component Difunctionalization of Unactivated Alkenes
1180
Dual NHC/Photoredox Catalysis for the Synthesis of β-CF3 (Hetero)Aryl Ketones
1181
Palladium-Catalyzed Enantioselective Aminoazidation Reaction of Unactivated Alkenes
1182
Tandem Trifluoromethylation and Cyanation/Etherification of Vinylamides and -esters
1183
Benzylic C–H Functionalization via Copper-Catalyzed Fluorination
1184
Enantioselective Coupling of Allylic Carbonates with Vinyl Azides by Iridium Catalysis
1185
Atroposelective Ring Opening of Cyclic Diaryliodonium Salts Using a Chiral Co Anion and Cu Catalyst
1186
Palladium-Catalyzed Dialkylation of Aromatics
1187
Alkenylation of Olefins with β-Nitrostyrenes
1188
Cobalt-Catalyzed Enantioselective Radical Cyclization of Alkenyl Alcohols
1189
Spiroaminals and Fused Bicycles via an Enantioselective Cyclopropanation–Rearrangement Protocol
1190
α-Arylation of Acetone using Aryl Chlorides and Nickel Catalysis
1191
Rhodium-Catalyzed Stereospecific Cyanomethylation of Tertiary Allylic Carbonates
1192
Hydroalumination of Allenes via Copper Catalysis for the Synthesis of β,γ-Unsaturated Ketones
1193
Carbonylative C(sp3)–H Activation for Synthesis of Amides and Esters
1194
Cleavage of C–O Bond in α-Alkoxy Ketones via Cobalt Catalysis
1195
Copper-Catalyzed Enantioselective Hydroacylation Reaction of Allenes
1196
Copper-Catalyzed ortho-Functionalization of Naphthols and Phenols
1197
Synthesis of Enantioenriched Isobenzofuranones via Bismuth and Phosphoric Acid Catalyzed Allylation
1198
Preparation of Functionalized 3-Arylpropanamides
1199
Corey–Fuchs Alkyne Synthesis
1200
ortho-Functionalization of Quinoline N-Oxides under Copper Catalysis

Polymer-Supported Synthesis

z1201
All PDFs of this category
1201
Hydrogenation of Alkynes to Alkenes on Pd NPs Supported on Cubic Cu in a Metal–Organic Framework
1202
Silylation of Aryl Chlorides on Palladium–Gold Alloy Nanoparticles Supported on Zirconia
1203
Anti-Markovnikov Regioselective Hydroamination of Alkenes with Aqueous NH3on a Au/TiO2Photocatalyst
1204
Iridium-Catalyzed Acceptorless Dehydrogenation of N-Heterocycles and Hydrogenation of N-Hetarenes
1205
Reduction of Carbonyl Compounds by Diethylsilane Catalyzed by Titania-Supported Gold Nanoparticles
1206
Carbon Nanotube Supported Ni/Pd-Nanoparticles on for Carbonylative Suzuki–Miyaura Coupling
1207
Aerobic Oxidation of Vanillic Alcohol with Pd/C and Sn-Pd/C
1208
Hydrogenation of Nitriles Catalyzed by Cobalt Phosphide Supported on Hydrotalcite
1209
Asymmetric Strecker Reaction Catalyzed by a Copper Porphyrin-Based Covalent Organic Framework
1210
Synthesis of N-Alkoxymethylated Benzimidazoles on Indium Oxide Nanoparticles

Organo- and Biocatalysis

z1211
All PDFs of this category
1211
Tetrapeptide-Catalyzed Dynamic Kinetic Resolution Grants Access to Helically Chiral Loratadine Analogues
1212
Confined N-Hydroxyimide-Catalyzed Site-Selective Radical Benzylic Amination
1213
A Catalytic Birch Reduction through a Consecutive Photoinduced Electron-Transfer Process
1214
Chiral Amine-Boronic Acid Catalysis: Enantioselective 1,4-Addition to α,β-Unsaturated Carboxylic Acids
1215
C4-Selective Alkylation of Pyridinium Salts Driven by Photoactivity of an Electron Donor–Acceptor Complex
1216
Highly Enantioselective and Stereodivergent Synthesis of Cyclopropyl δ-Lactones
1217
Quinacridinium Ion as a Versatile Organic Photoredox Catalyst for Red-Light-Mediated Reactions
1218
Enantioselective Synthesis of α-Amino Ketones by Asymmetric Counteranion-Directed Catalysis
1219
A New Catalytic Radical-Based α-Deoxygenation of Benzoin Derivatives
1220
Organophotocatalytic Boron-Mediated Geometric Isomerization of Alkenes

Chemistry in Medicine and Biology

z1221
All PDFs of this category
1221
A Long-Lasting HIV-Capsid Inhibitor
1222
Orexin-1-Receptor-Selective Antagonists through Structure-Based Drug Design
1223
Peptide Antagonist of CGRP Receptor for Migraine Treatment
1224
Light-Controlled Carbonation
1225
6-Aza-artemisinins as Potent Antimalarial Drugs
1226
Depalmitoylation Strategy to Inhibit NRAS Signaling
1227
Hapten Deuteration of a Heroin Vaccine
1228
Structural Modification of Oridonin Yields A More Potent Anticancer Agent
1229
Total Synthesis of N14-Desacetoxytubulysin H Using Passerini Multicomponent Reaction (MCR)
1230
Janelia Fluor Photosensitizers
1231
Covalent Inhibitors for PIP Signaling
1232
Maleimides Allow for Cycloaromatization of Acyclic Enediynes
1233
Efficient Total Synthesis of Lipid I and Lipid II Analogues
1234
SYK Inhibitor with Improved hERG-Profile
1235
Dansyl’s First Dance

Peptide Chemistry

z1237
All PDFs of this category
1237
Coupling of Amino Acids and α-Branched Aldehydes
1238
Vicinal Tetrasubstituted Oxindole-Derived Acyclic Amino Acid Synthesis by a Mannich-Type Reaction
1239
One-Pot Synthesis of β-Amino Secondary Amides from Vinylic Azides and N-Acyl Imines
1240
Efficient Method for Peptide Synthesis in Water by Using Amphiphile PS-750-M
1241
Metallaphotoredox-Catalyzed Synthesis of γ-Amino Acid Derivatives
1242
[3+2]-Cycloaddition Reaction for the Synthesis of Spirocyclic α-Amino Esters
1243
Cu-Catalyzed Ligand-Controlled Synthesis of β-Amino Acid Derivatives
1244
Synthesis of Fluorinated Quaternary α-Amino Acid Esters
1245
Photoredox Decarboxylative Coupling for α-Amino Acids Synthesis
1246
Copper-Catalyzed C(sp3)–H Bond Activation to Access α-Alkoxylated Amino Amide Derivatives
1247
Synthesis of Reactive Amino Acid Esters by Using 9-Fluorenylmethyl Chloroformate

Flow Chemistry

z1249
All PDFs of this category
1249
Selective Monoreduction of a Pyridine Diester on a Kilogram Scale
1250
Development of an Efficient Flow Hydroformylation in a High-Throughput Single-Droplet Reactor
1251
Scalable Electrochemical Cyclobutane Synthesis in Continuous Flow
1252
Photocatalytic Carbonylative Amidation in Continuous Flow
1253
Polymer-Supported Tin-Catalyzed Synthesis of Tetrazoles in Flow
1254
Synthesis of Heteroaryl Sulfinates in Continuous Flow for Use in Palladium-Catalyzed Cross-Coupling
1255
Aryl Amine Synthesis in an Integrated Packed-Bed Flow System