Trimethylaluminum-Mediated Peptide Synthesis

Key words

trimethylaluminum - solution-phase synthesis - peptide coupling - unprotected amino acids

Significance

The amide bond is ubiquitous; in particular, it is present in the backbones of peptides and in many natural products. Consequently, it has gained considerable importance in organic synthesis. Chemists are therefore continually searching for new methods for amide and/or peptide bond-forming reactions. In 1998, Martin and co-workers invented an AlMe₃-mediated peptide synthesis from unprotected amino acids in the solution phase.

Comment

This inexpensive AlMe₃-mediated solution-phase amide bond forming reaction proceeds smoothly to afford the desired products in moderate to good yields. The method can also be applied in syntheses of tripeptides in moderate yields.

Publikationsverlauf

Artikel online veröffentlicht:
18. August 2021