DOI: 10.1055/s-00000131

Synfacts

Issue 09 · Volume 17 · September 2021 DOI: 10.1055/s-011-51728

Synform

A139
Zanda, Matteo: SYNFORM ISSUE 2021/09

Synthesis of Natural Products and Potential Drugs

z959
All PDFs of this category
0959
Total Synthesis of (+)-Fortalpinoid A and (+)-Cephinoid H
0960
Synthesis of (±)-Jujuyane
0961
Synthesis of PF-06873600
0962
Divergent Synthesis of Pentacyclic Cytochalasans
0963
2-Sulfinyl-Diazabicyclooctane Derivatives as β-Lactamase Inhibitors
0964
Synthesis of BACE1 Inhibitor PF-06751979
0965
Total Synthesis (+)-Samroiyotmycin A
0966
Total Synthesis of (–)-Spiroxins A, C, and D
0967
Synthesis of (–)-Halichondrin B
0968
Synthesis of (±)-Paeoniflorigenin

Synthesis of Heterocycles

z0969
All PDFs of this category
0969
Radical Azidation of Cyclopropenes
0970
One-Pot, Two-Step Synthesis of Indole-Fused Diazepanones
0971
Regioselective C–H Borylation via Minisci-Type Reaction
0972
Synthesis of Fluoroalkylated Isoquinolinones via Cobalt-Catalyzed C–H Activation/Annulation
0973
Synthesis of Multisubstituted Pyridines via Nickel Catalysis
0974
One-Pot Knoevenagel Condensation–Reduction Reaction of 2,4-Dihydroxy Quinolines and Pyridines
0975
Umpolung Strategy to Functionalize Pyridines/Quinolines via Phosphonium Intermediates
0976
Rhodium(III)-Catalyzed Synthesis of Functionalized Dihydrobenzofurans
0977
Catalyst-Free Amination of Quinoxalin-2-ones and Benzo[1,4]oxazin-2-ones by Visible Light
0978
Heterogeneous Nickel Catalyst Promotes Indole Formation via Dehydrogenative Coupling
0979
Eight-Membered Cyclic Amines via Morpholine Intermediates
0980
Room-Temperature C–N Coupling with Aryl Chlorides

Synthesis of Materials and Unnatural Products

z0981
All PDFs of this category
0981
May the ‘London Dispersion Force’ Be with You
0982
Triple Oxa[7]Helicene With High Dissymmetry Factor
0983
A Family of Benzothienothienothienoindoles
0984
Mimicking Flavin in Polyaromatic Hydrocarbons
0985
An Enantioselective Host for Carbohelicenes
0986
Chemoselectivity of Nucleophilic Addition Controlled by Triple Helicene Geometry
0987
Borane-Catalyzed Block Copolymerization and Selective Polycarbonate Degradation
0988
Mild Synthesis of (E)-β-Amidovinyl Sulfones
0989
Building the Cyclothianthrenes Family
0990
Avoiding Cyanide in Cyanoformate Synthesis
0991
Air Tautomerism Yielding Quinoidal Compounds
0992
Pre-Polymerization Fluorine Functionalization of Polymers of Intrinsic Microporosity (PIMs)

Metals in Synthesis

z993
All PDFs of this category
0993
Enamide Synthesis from Amides Using Tf2O for Electrophilic Activation
0994
Photocatalyzed Sulfinylation of Strong, Unactivated Aliphatic C(sp3)–H Bonds
0995
Enantioconvergent Photoinduced Copper-Catalyzed Synthesis of Chiral Secondary Amides
0996
Cobalt-Catalyzed Enantioselective Desymmetritive Cycloaddition Generating Pyridines
0997
Iridium-Catalyzed Enantioselective Hydrocarbonation of Alkenes
0998
Catalytic Asymmetric α-Arylation of Aldehydes
0999
Aluminum-Catalyzed Borylation of Alkynes
1000
Switchable endo/exo-Selectivity in a Nickel-Catalyzed Domino Heck Cyclization
1001
[5+2] Annulation of 1-Indanones and Alkynes via Rhodium-Catalyzed C–C Activation
1002
Pd/Cu Dual-Catalyzed Directed Carbonylative Arylborylation of Unactivated Alkenes
1003
Selective Difluoroallylations with 3,3-Difluoroallyl Ammonium Salts
1004
Allylation of 2-Azaallyls with Allyl Ethers
1005
Electroreductive Nozaki–Hiyama–Kishi Reaction
1006
Synthesis of Congested β-Stereogenic Amines via Asymmetric Iridium-Catalyzed Allylation of Nitroalkanes
1007
Co-Catalyzed C–H Activation and Diastereoselective Annulation Cascade Towards the Synthesis of Indanes
1008
Difluoromethylation of Alkenes
1009
Photoinduced 1,2-Dicarbofunctionalization of Alkenes
1010
Ligand Design for the Palladium-Catalyzed Cross-Coupling of Nitroarenes and Phenols
1011
Enantioselective Dearomative Alkylation of 4-Methoxypyridinium Ions
1012
Asymmetric [3+2] Cycloaddition via Rh/Pd Synergistic Catalysis
1013
Difunctionalization of Alkenes via Copper Catalysis Generated Oxocarbenium Ion
1014
Arylation and Alkenylation of Cyclopropanols
1015
Enantioselective Reverse Hydroboration of α,β-Unsaturated Amides
1016
Rhodium-Catalyzed Reactions of Boronic Acids with Cyclobutenes
1017
1,4-Hydroboration of CF3-Substituted Dienes via Copper Catalysis
1018
Decarbonylative Sonogashira Cross-Couplings
1019
The Hosomi–Sakurai Reaction
1020
A Bifunctional Tautomeric Ligand for Pd-Catalyzed C(sp2)–H Hydroxylation Using Oxygen as the Oxidant

Polymer-Supported Synthesis

z1021
All PDFs of this category
1021
C–H Oxidation of Hydrocarbons Catalyzed by Iron Immobilized on COF Nanospheres and NanoFilms
1022
Asymmetric Ring-Opening and Hetero-Diels–Alder Reactions on a Supported Chiral Salen–Cr Complex
1023
Aromatic Substitution in Water by Using a Polymeric Amphiphilic Additive
1024
C–N and C–O Cross-Couplings of Aryl Iodides Catalyzed by Reusable Copper Nanoparticles
1025
Hydrogenation and Tandem Reactions of Nitroarenes on N-Doped Carbon−Coated Cobalt Nanoclusters
1026
Dynamic Kinetic Resolution with a Palladium Nanoparticle–Lipase Hybrid Catalyst
1027
Catalyst-Free Electrochemical C-3 Formylation of Indoles in an Aqueous Biphasic System
1028
Copper-Catalyzed Dehydrogenative Coupling of Primary Amines: Preparation of Amides and Imines
1029
Transfer Vinylation of Alcohols by Butyl Vinyl Ether on DMF-stabilized Palladium Nanoparticles
1030
Synthesis of Carboxylic Acids from Styrene Derivatives and Fatty Acids through Oxidative C=C Bond Cleavage
1031
Heterogenized Photocatalyst for Condensation of 4-Hydroxycoumarin, Dimedones, and Benzaldehydes

Organo- and Biocatalysis

z1033
All PDFs of this category
1033
Enzymatic Intra- and Intermolecular Hydroalkylations of Alkenes through Ground-State Electron Transfer
1034
Tripeptide-Catalyzed N-Oxidation Enables Enantioselective Desymmetrization of Sulfoximines
1035
Aminocatalytic α-Enantioselective Etherification of Branched Aldehydes
1036
Efficient Access to Contiguously Substituted Tetrahydronaphthols through Dienamine Catalysis
1037
Atropisomeric Multiaxis Aldehyde Permits Epoxidation of Nonactivated Olefins with H2O2 as the Oxidant
1038
Prolinol-Derived Catalysts Mediate Route Towards Functionalized trans-Diels–Alder Products
1039
Chiral N-Heterocyclic Carbene Bifunctional Organocatalyst for Aza-Michael Addition Reactions
1040
Organophotocatalytic Hydroxymethylation of Secondary Alkyl Iodides
1041
Enantioselective [2+2] Photocycloaddition Catalyzed by Sensitizer-Modified Chiral Phosphoric Acid
1042
Organophotocatalytic Strict Temporally Controlled Cationic Polymerization of Vinyl Ethers

Chemistry in Medicine and Biology

z1043
All PDFs of this category
1043
X-ray Irradiation Promoted Activation of Prodrugs
1044
Go Bi-Steric for Selectivity
1045
Goyazensolide, a Covalent Importin‑5 (IPO5) Inhibitor
1046
Truncated Mycalolide B Analog to Prevent Cancer Metastasis
1047
Macrodiolide Library Synthesis of cGAS-STING Inhibitors
1048
Spiro-Trycyclic Alkaloids as nAChR Antagonists
1049
Targeting Transcription Factors for Degradation
1050
Fighting Malaria with Endoperoxides
1051
Cyclic Disulfides as Selective Thioredoxin Probes
1052
Total Synthesis of Pyrrolylpyrromethane Alkaloids with Antimalarial Activity
1053
Total Synthesis and Configurational Assignment of Mutanobactin D
1054
Total Synthesis and Structure-Activity Studies of Geodiamolide H
1055
Drugging the Undruggable using Irreversible Covalent K-Ras G12C Inhibitors

Peptide Chemistry

z1057
All PDFs of this category
1057
Solar Radiation-Assisted Peptide-Bond Formation
1058
C(sp3)–H Functionalization for Modification of Peptides with Alanine at the C-Terminus
1059
Nickel-Catalyzed Synthesis of α-Amino Acid Derivatives
1060
Photocatalytic Phosphotyrosine Mimetic Functionalization of Peptides
1061
Enantioselective Synthesis of α-Amino Acid Esters by Rhodium/Copper Catalysis
1062
Photoredox Amidation of Tryptophan in Peptides
1063
Late-Stage Palladium-Mediated N-Arylation of p-Aminophenylalanine in Unprotected Peptides
1064
Hybrid Peptide Synthesis by Radical–Radical Coupling
1065
Trimethylaluminum-Mediated Peptide Synthesis
1066
Palladium(II)-Catalyzed C(sp2)–H Functionalization of Tryptophan and Tryptophan-Containing Peptides

Flow Chemistry

z1067
All PDFs of this category
1067
Electrochemical Fluorination Reactions in Continuous Flow Using (Difluoroiodo)arene Mediators
1068
Synthesis of α-Amino Acids by Electrochemical Carboxylation of Aldimines in a Flow System
1069
Copper-Catalyzed Hydrosilylation of Alkynes and Alkenes under Blue LED Irradiation
1070
Z-Selective Olefin Metathesis in Continuous Flow