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Synfacts 2021; 17(09): 0959
DOI: 10.1055/s-0040-1720836
Synthesis of Natural Products and Potential Drugs

Total Synthesis of (+)-Fortalpinoid A and (+)-Cephinoid H

Contributor(s):
Erick M. Carreira
,
David M. Fischer
Ren Z, Sun Z, Li Y, Fan X, Dai M, Wang Y, Hu X. * Northwest University, Xi'an, P. R. of China
Total Synthesis of (+)-3-Deoxyfortalpinoid F, (+)-Fortalpinoid A, and (+)-Cephinoid H.

Angew. Chem. Int. Ed. 2021;
60: 18572-18576
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Key words

cephalotaxus - (+)-fortalpinoid A - (+)-cephinoid H - Pauson–Khand cyclization - ring-closing metathesis

Significance

Hu and co-workers report the first total synthesis of (+)-fortalpinoid A and (+)-cephanoid A, members of a class of 17,17-norditerpenoids, isolated from Cephalotaxus fortunii.


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Comment

Allyl alcohol B is accessed from vinylogous ester A, first described by Myers and co-workers, and elaborated into enyne D, which then undergoes the key carbonylative cyclization to furnish E and give access to three natural products.


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Publication History

Article published online:
18 August 2021

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