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Synfacts 2021; 17(09): 1057
DOI: 10.1055/s-0040-17119953
Peptide Chemistry

Solar Radiation-Assisted Peptide-Bond Formation

Contributor(s):
Hisashi Yamamoto
,
An Wu
Mishra AK, Parvari G, Santra SK, Bazylevich A, Dorfman O, Rahamim J, Eichen Y, *, Szpilman AM. * Technion – Israel Institute of Technology, Haifa and Ariel University, Israel
Solar and Visible Light Assisted Peptide Coupling.

Angew. Chem. Int. Ed. 2021;
60: 12406-12412
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Key words

peptide bond formation - photocatalysis - solar radiation - bromotrichloro­methane - radical reaction

Significance

Amide bond formation is extremely important in peptide chemistry. The authors have developed a sunlight-assisted method for generating active coupling reagent in situ from readily available DMAP and bromotrichloromethane to form peptide bonds.


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Comment

Various dipeptides can be synthesized by using DMAP and bromotrichloromethane to generate the active coupling reagent. The reactions proceed rapidly, and the yields of the desired peptides are good to excellent.


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Publication History

Article published online:
18 August 2021

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