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Synfacts 2021; 17(04): 0399
DOI: 10.1055/s-0040-1719438
Metals in Synthesis

Iron-Catalyzed Asymmetric Carboazidation of Styrenes

Contributor(s):
Mark Lautens
,
Austin D. Marchese
Ge L, Zhou H, Chiou M.-F, Jiang H, Jian W, Ye C, Li X, Zhu X, Xiong H, Li Y, Song L, Zhang X, *, Bao H. * Peking University, Shenzhen; University of Chinese Academy of Sciences, Beijing; Chinese Academy of Sciences, Fuzhou, Fujian, P. R. of China
Iron-Catalysed Asymmetric Carboazidation of Styrenes.

Nat. Catal. 2021;
4: 28-35
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Key words

iron catalysis - asymmetric synthesis - difunctionalization - azides

Significance

The authors report the use of a NON-pincer ligand for the asymmetric iron-catalyzed carboazidation reaction of styrenes. A variety of alkyl halides generating stabilized radicals were used.


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Comment

A complex system involving synergistic effects of both van der Waals and π-interactions were found to be responsible for the stereocontrol of the reaction.


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Publication History

Article published online:
18 March 2021

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