DOI: 10.1055/s-00000131

Synfacts

Issue 04 · Volume 17 · April 2021 DOI: 10.1055/s-011-50572

Synform

A49
Zanda, Matteo: SYNFORM ISSUE 2021/04

Synthesis of Natural Products and Potential Drugs

z0363
All PDFs of this category
0363
Total Synthesis of (+)-Peniciketal A
0364
Total Synthesis of (+)-Mycinolide IV
0365
Synthesis of PF-07059013
0366
Synthesis of ent-Plagiochianin B
0367
Synthesis of (–)-Dehydrocostus Lactone
0368
Synthesis of Eldecalcitol
0369
Synthesis of PF-06843195
0370
Synthesis of DS79932728
0371
Synthesis of Ceralasertib
0372
Synthesis of (–)-Euonyminol
0373
Total Synthesis of (±)-Longifolene
0374
Total Synthesis of (+)-Punicafolin and (+)-Macaranganin

Synthesis of Heterocycles

z0375
All PDFs of this category
0375
Rhodium(III)-Catalyzed C–H Activation/Annulation To Form Isoquinolone Scaffolds
0376
Chiral Phosphoric Acid Catalyzed Enantioselective Synthesis of 8-Azabicyclo[4.3.1]decanes
0377
Preparation of Imidazolidine-2-ones from N-Benzoyloxyureas by C–H Amination
0378
Nickel/Copper-Catalyzed Amidation of 2-Iodoglycals to Access Glycosamine Analogues
0379
Palladium-Catalyzed Synthesis of Azepines from Pyrrolidines
0380
Three-Component Approach to Indoles
0381
Synthesis of N-Fused Hetarenes from Alkenes
0382
N-Containing Bicyclic Heterocycles by Annulation of 2H-Azirines with 2-Chloropyridine Derivatives
0383
Et3N-Direct Cycloaddition of Allenoates with Acceptor Diazo-Compounds
0384
Diastereoselective Synthesis of 2,3-Dihydrofurans from Silver Allenes
0385
Synthesis of Enantiomerically Enriched Chiral 1-Pyrrolines

Synthesis of Materials and Unnatural Products

z0387
All PDFs of this category
0387
From Saddles to Helices
0388
Easy as 1,2,3,4-Tetrasubstituted Benzenes
0389
An Expedient Approach to a Zigzag Carbon Nanobelt
0390
Stereospecific Synthesis of Pyrene-Fused [5]Helicenes
0391
Flip-Flopping Nanohoops
0392
BRB, Looking for Aromaticity
0393
Easy as 8π
0394
Efficient Synthesis of azahelicenes through Imine-Based Mallory Cyclization
0395
Alternative Retrosynthetic Approach towards Synthesis of Nile Red Analogues
0396
Facile Functionalization of 6-Aryl-2,20-bipyridines
0397
No Resolution Necessary
0398
Novel Synthesis of Piperidinium-Functionalized Polyethylene for Alkaline Anion Exchange Membranes

Metals in Synthesis

z0399
All PDFs of this category
0399
Iron-Catalyzed Asymmetric Carboazidation of Styrenes
0400
Diastereoselective Synthesis of (Spiro)Indanones by Nickel-Catalyzed Reductive Cyclization
0401
Acyl Chlorides as Dual Source of Carbon Nucleophile and Carbon Monoxide
0402
Enantioselective Nickel Hydride Catalyzed Cross Coupling of Alkyl Electrophiles
0403
Pd(0)-Catalyzed, Stereoselective Intermolecular Cycloaddition: Towards Substituted Cyclopentanes
0404
α-Arylation of Ketones with Nitroarenes
0405
Asymmetric Hydroarylation of N-Acyl Enamines
0406
4-Thiooxazole Synthesis and Sulfanyl–Lithium Exchange
0407
Palladium-Catalyzed Z-Selective Dienylations
0408
Silver-Catalyzed Heteroarylation of Aliphatic Alcohols in Water
0409
Site-Selective Silver-Catalyzed C−H Bond Deuteration of Five-Membered Heterocycles
0410
Chiral Aldehydes from Cycloproyplacetylenes via Palladium/Organo Dual-Catalysis
0411
Pd-Catalyzed Enantioselective Carbohalogenation Employing a H-Bonding Driven Reductive Elimination
0412
Palladium-Catalyzed C–H Addition to Nitriles: α-Iminol Rearrangement
0413
Scandium-Catalyzed Asymmetric Homologation of Ketones using α-diazo Esters
0414
Photoredox Catalysis: Decarboxylative Cross-Coupling of Nitrones with α‑Amino Acids
0415
Enantio- and Diastereoselective Conjugate Addition of Borylalkenes to α,β-Unsaturated Diesters
0416
Asymmetric Heck–Matsuda Reaction for the Preparation of β-Chiral Ketones
0417
Enantioselective Sulfimidation of Pyridones and Quinolones via Silver Catalysis
0418
Copper-Catalyzed Asymmetric Alkylamination of Unactivated Alkenes Generating β-Lactams
0419
Generation of Secondary and Tertiary Alcohols via Anaerobic Mukaiyama-Type Hydration
0420
meta-Selective C–H Functionalization of Phenols
0421
Palladium-Catalyzed Carbonylation of 1,3-Dienes
0422
Asymmetric Synthesis of 4-Aryl-3,4-dihydrocoumarins by Palladium-Catalyzed Hydroesterification
0423
Hydrofuctionalization of Styrene via a Photoredox Process Catalyzed by a Decatungstate Complex
0424
Nickel-Catalyzed Enantioselective Hydroalkylation of Enecarbamates
0425
Copper-Catalyzed Enantioselective Vinylogous Aldol Reaction of Allylazaarenes
0426
Asymmetric Conjugate Addition of 1,1-Diborylmethane
0427
Directed ortho-Lithiation of Benzamides

Polymer-Supported Synthesis

z0429
All PDFs of this category
0429
Synthesis of Alkynylcyclopentenols on a Foam-Supported Palladium Catalyst
0430
Dehydrogenative Condensation of Anilines with Dioles on Platinum/Alumina
0431
One-Step Deoxydehydration–Transfer Hydrogenation of Sugar Acids with a Pt–Re Oxide Catalyst
0432
Supported Cobalt Phosphide Nanoalloy Catalysts for Hydrogenation of Furfurals
0433
Synthesis of Spiro-4-thiazolidinones on a Porous Polymeric Ionic Liquid Containing Co3O4
0434
Hydrocarboxylation of Alkenes Catalyzed by Rhodium Supported on Porous Organic Polymer
0435
Heterogeneous Gold-Nanoparticle-Catalyzed Stille Coupling of Benzylic Bromides and Allylstannanes
0436
Cobalt-Catalyzed Reductive Alkylation of Nitriles with Aldehydes or Ketones
0437
Selective Oxidation of Alcohols with TEMPO Supported on Hollow Porous Aromatic Frameworks
0438
Gold/Titania-Catalyzed Borylation of Allylic, Propargylic, and Benzylic Esters

Organo- and Biocatalysis

z0439
All PDFs of this category
0439
Photoenzymatic Intermolecular Hydroalkylation of Alkenes
0440
Asymmetric Photoredox Dearomatization of Indoles by Neutral α-Amino Radicals
0441
Photoenzymatic Reduction of α,β-Unsaturated Amides with Ene-Reductases
0442
BINOL-Derived Photoswitchable Phase-Transfer Catalysts
0443
Synthesis of a Chiral Pentafluorinated Isopropyl Group by Aryl Iodide Catalyzed Difluorination of Styrenes
0444
N-Fluorosulfonyl Carbamate and Organoiodine Catalysis: Vicinal Heterodifunctionalization of Olefins
0445
Synergistic Dual Organocatalysis for Highly Selective Michael Additions
0446
Catalytic Asymmetric Chloroamidation of Allylic Amides
0447
High Lewis Acidity of Bidentate Iodine(III)-Based Halogen-Bond Donors
0448
Photocatalytic Minisci Alkylation of Azaarenes
0449
Room-Temperature Carbon Isotope Exchange of Carboxylic Acids Through Photoredox Catalysis

Chemistry in Medicine and Biology

z0451
All PDFs of this category
0451
Sucrose Analogues for Real-Time Imaging of Intracellular Plant Metabolism
0452
Total Synthesis of Cephalosporin C
0453
Optical Control of the Cannabinoid Receptor 2
0454
Novel Prodrugs for Targeted Cancer Therapy
0455
Light-Induced Cell Cycle Arrest and Apoptosis
0456
A Potent Preclinical Plasmodium Proteasome Inhibitor
0457
Modular Chemoenzymatic Synthesis of GE81112 B1
0458
Diversity-Focused Semisynthesis of Polyether Ionophores with New Antibacterial Selectivity
0459
Evaluation of C2−C2′ Bond Stereochemistry Influence on Cytotoxicity of (–)-Lomaiviticin A

Peptide Chemistry

z0461
All PDFs of this category
0461
Ball-Milling Strategy for Epimerization-Free Peptide Synthesis
0462
Rhodium-Catalyzed Synthesis of β2/γ2/δ2-Amino Acid Derivatives
0463
Synthesis of All-Alkyl α-Tertiary Amino Acid Derivatives under Visible-Light Irradiation
0464
β-Seleno-α-Amino Acids Synthesis by Seleno-Michael Additions to Bicyclic Dehydroalanine
0465
Photocatalyzed Modification for Tryptophane-Containing Peptides
0466
Triflic Acid Catalyzed N–H Insertion Reaction for the Synthesis Unnatural α-Amino Esters
0467
Synergistic Brønsted Acid/Photoredox Catalysis for the Synthesis of α-Amino Acids
0468
Rhodium-Catalyzed Formation of Proline Analogues
0469
Peptide Bond Formation by Using 2-Pyridyl Thio Esters

Flow Chemistry

z0471
All PDFs of this category
0471
Halogen–Lithium Exchange on Isothiocyanate-Substituted Aryl Halides
0472
Safer Handling of Diazomethane through Continuous Generation and Consumption
0473
Oxidative Debenzylation of Protected Carbohydrates under Flow Conditions
0474
Synthesis of Aminoimidazo Heterocycles under Flow Conditions
0475
Generation and Use of Lithiated 1-Azabicyclo[1.1.0]butanes in Flow Microreactors
0476
Selective Oxidation of Alcohols under Flow Conditions