Cai W,
Qiao X,
Zhang H,
Li B,
Guo J,
Zhang L,
Chen W.-W,
Zhao B.
*
Shanghai Normal University, P. R. of China
Asymmetric Biomimetic Transamination of α-Keto Amides to Peptides.
Nat. Commun. 2021;
12
Key words
transamination - organocatalysis - asymmetric catalysis - keto amides - peptides
Significance
Peptide synthesis is important in drug discovery and medicinal chemistry. The authors have developed an asymmetric transamination method for synthesizing peptides from α-keto amides.
Comment
By using an N-quaternized axially chiral pyridoxamine as a catalyst, a wide range of dipeptides can be synthesized from α-keto amides in good to excellent yields. This transamination method can also be applied in peptide elongation to synthesize peptide chains containing unnatural amino acids.
