DOI: 10.1055/s-00000131

Synfacts

Issue 12 · Volume 17 · December 2021 DOI: 10.1055/s-011-52323

Synform

A193
Zanda, Matteo: SYNFORM ISSUE 2021/12

Synthesis of Natural Products and Potential Drugs

z1299
All PDFs of this category
1299
Total Synthesis of (+)-Heilonine
1300
Total Synthesis of (±)-Peyssonnoside A
1301
Synthesis of AZD7624
1302
Synthesis of JNJ-67569762
1303
Synthesis of (+)-Agarozizanol B
1304
Synthesis of EEDi-5273
1305
Synthesis of PARP1–DNA Trapper AZD5305
1306
Synthesis of MK-8262
1307
Total Synthesis of (+)-Massarinolin A
1308
Total Synthesis of (–)-Complanadine A and (–)-Lycodine
1309
Synthesis of Aficamten
1310
Synthesis of YLF466D
1311
Synthesis of a Cyclic Glutamine Analogue Used in Antiviral Agents
1312
Synthesis of CY6463
1313
Synthesis of Belvarafenib
1314
Synthesis of BMS-986158
1315
Total Synthesis of (±)-Cochlearol B
1316
Synthesis of Thromboxane A2

Synthesis of Heterocycles

z1317
All PDFs of this category
1317
Demonstrated 6-endo-tet Cyclizations!
1318
Silver-Catalyzed Synthesis of Optically Active Pyrrolo[3,4-b]indoles
1319
7-Alkylidene-Containing Bridged Azabicycles by Tandem Palladium and Copper Catalysis
1320
4-(Perfluoralkyl)triazole-5-Carboxylates
1321
5-Substituted 2-Alkyl-1H-Tetrazoles
1322
Screening Platform for Optimizing Nickel-Catalyzed Suzuki–Miyaura Reactions
1323
Chemoselective N- and O‑Difluoromethylation of 2‑Pyridones, Isoquinolinones, and Quinolinones
1324
Oxazolines, Pyrrolidines, and Dihydrooxazines by Photochemical C(sp3)–H Functionalization
1325
Hydrosilane-Facilitated Reduction of Pyridines through Borenium Catalysis
1326
Versatile 7-Azaindole Intermediates
1327
Nickel-Mediated Enantioselective Piperidine Synthesis
1328
Metal-Free Synthesis of 4‑Aryl-1,2,3-triazoles by Iodine‑Promoted Cyclization
1329
Access to Nonsymmetrical Tri- and Tetraoxanes with Silica Sulfuric Acid
1330
Deoxidative Amination of Azine N-Oxides

Synthesis of Materials and Unnatural Products

z1331
All PDFs of this category
1331
Escape from Flatland
1332
If I Had a Nickel for Every Macrocycle…
1333
Fjord Exploration
1334
α,ω-Bisfunctionalized Oligo(ortho-arylenes): One Step at a Time
1335
Hoop Dreams: Scalable Synthesis of Cycloparaphenyleneacetylene
1336
The Sonogashira Coupling of Sulfonium Salts
1337
Cyclic Polyacetylene
1338
A Macrocyclic Radicaloid
1339
Controlled Polyacetal Polymerization
1340
Mild Synthesis of N-Vinylindole
1341
Convergent Branching in ROMP
1342
Synthesis of 3-(2-Cyano)indolyl Substituted Geminal-Difluoroalkenes

Metals in Synthesis

z1343
All PDFs of this category
1343
Copper-Catalyzed Borocarbonylation of Styrenes
1344
Manganese-Catalyzed Ring-Opening Fluorination of Strained Cyclic Alcohols
1345
Aza-Matteson Homologations: Selective Mono- and Double-Carbenoid Insertions into Aminoboranes
1346
Iridium-Catalyzed C–H Alkylative Annulation of Arenes Using Ketones as an Alkyl Radical Source
1347
Palladium-Catalyzed Dearomative Domino-Heck Reaction of Naphthols
1348
Preparation of β-Chloro Esters at the Drop of the Hat: A Photocatalyzed Alkoxycarbonylation of Alkenes
1349
Palladium-Catalyzed, Atom-Economic Transfer of Acid Chlorides Across Unsaturated C–C Bonds
1350
Ruthenium-Catalyzed Enantioselective Addition of Carboxylic Acids to Allenes Generating Allylic Esters
1351
Holding Hands through Azide Ions: Dual Catalytic Alkene Azidoarylation
1352
Enantio- and Diastereodivergent Synthesis of Spirocycles via Dual Metal Catalysis
1353
Walking Tungsten: Site-Selective Remote Hydroboration of Unactivated Alkenes
1354
Preparation of Aryl Esters from Primary Alcohols and Phenols under Photoredox Catalysis
1355
A Nickel/Photoredox Dual Catalytic Platform for Late-Stage Functionalization of N-Me Trialkylamines
1356
Palladium-Catalyzed Synthesis of Fluorinated Isoindoles
1357
Nickel-Catalyzed Intramolecular Coupling of C–H Bonds
1358
Accessing α-Chiral Primary Amines via Copper-Catalyzed C–N Coupling using Ammonia Surrogates
1359
Enantioselective Catellani-Type Reaction via Palladium–Enamine Cooperative Catalysis
1360
Stilbene Takes the Fall: A Triplet-Energy-Transfer Inhibiting Strategy for Benzylic C–H Alkenylation
1361
Magic with Manganese: A Highly Selective Allylic C–H Amination of Complex Olefins
1362
Protecting Group-Controlled Dearomative Arylboration of Indoles Catalyzed by Nickel
1363
Stereoconvergent Cross-Electrophile Coupling of Styrene Oxides Enabled by Ni/Photoredox Catalysis
1364
Asymmetric Synthesis of Allenyl Nitriles by Radical Cyanation of Benzyl Alkynes
1365
Copper-Catalyzed Asymmetric Allylic Alkylation of Homoenolates Derived from Cyclopropanols
1366
The Tsuji–Wilkinson Decarbonylation

Polymer-Supported Synthesis

z1367
All PDFs of this category
1367
Oxidative Cleavage and Esterification of Styrenes Promoted by Tubular Carbon Nitride
1368
C–H Oxidation and Asymmetric Epoxidation with Porous Polymeric Manganese Complexes
1369
Carboxylation and Carbonylation of Aryl Halides by Formic Acid on a Li-Modified Pd/Co3O4 Catalyst
1370
Synthesis of 1,3,4-Oxadiazoles on Nickel Nanoparticles Supported on a Porous Cross-Linked Polymer
1371
Photoinduced Nickel-Catalyzed Aromatic Etherification
1372
Synthesis of Indenopyridopyrimidenes on Nickel-Ferrite-Immobilized Copper(I) Nanoparticles
1373
N-Formylation of Amines Catalyzed by Fe3O4–CuO Nanocomposites
1374
Oxidative Cyanation of Aldehydes on Se,S,N-Doped Porous Carbon Nanosheets
1375
Regioselective C–H Arylation of Thiophenes on a Ni-Coordinated Porous Phenanthroline-Derived Polymer
1376
Hydroxylation of Arylboronic Acids to Phenols on a Vanadia–Titania Catalyst
1377
Selective Hydrogenation of (2-Furyl)alkanones with H2 or H2/CO2 Catalyzed by Ruthenium
1378
Mesoporous Carbon-Catalyzed Oxidative Amination of C-Methyl Groups in N-Heterocycles

Organo- and Biocatalysis

z1379
All PDFs of this category
1379
Enzymatic Nitrene Insertion into C–H Bonds for Synthesis of Enantioenriched Amides
1380
Synthesis and Applications of Lewis Superacidic Catecholato Phosphonium Ions
1381
Strong and Confined Brønsted Acid Catalyst Enables Isotactic Polymerization of Vinyl Ethers
1382
Electrochemical Asymmetric Shono-Type Oxidative Coupling of N-Arylglycine Esters and Ketones
1383
An Aryl Iodide Catalyzed Bora-Wagner–Meerwein Rearrangement
1384
Modular Approach to Tunable Imidodiphosphate-Based Brønsted Acid Catalysts
1385
N-Heterocyclic Carbene Catalyzed Hydrophosphination of α-Bromoenals
1386
Brønsted Acid Catalyzed Metathesis/Rearrangement of 1H-Isochromene Acetals and Vinyl Diazo Esters
1387
Organophotocatalyst Engages in Hydroaminoalkylation of Unprotected Amines and Styrenes

Chemistry in Medicine and Biology

z1389
All PDFs of this category
1389
On-Demand Synthesis of Modified Oligonucleotides
1390
Design and Development of Dual 5-HT3R/5-HT6R Antagonists
1391
Stable Colibactin Analogues Enable Mechanism of Action Studies
1392
Off-Switch Rapamycin
1393
Catalytic eDHFR Acylation in HEK293T Cells
1394
Pyrrole Hemithioindigos: The New Photoswitch on the Block
1395
Straight to the Heart of the Problem: Factor XIa Inhibitor for Antithrombotic Therapy
1396
Assessment of GSK2798745 Metabolite
1397
A Solid Way to Purify Polyethylene Glycols
1398
A Novel Covalent Bruton’s Tyrosine Kinase Inhibitor
1399
KEAP on Searching for Novel E3 Ligases
1400
Wittig Reagents for Sulfenic Acid Ligation
1401
Keep in Mind: An Oxadiazine as Gamma Secretase Modulator for Treating Alzheimer’s Disease

Peptide Chemistry

z1403
All PDFs of this category
1403
Peptide Synthesis by Asymmetric Transamination of α-Keto Amides
1404
Nickel-Catalyzed Cross-Coupling of α-Amino-β-bromocarboxylic Acid Esters with Aryl Bromides
1405
One-Pot Approach for Diastereoselective β-Lactam Synthesis
1406
Photoredox-Catalyzed Amidation of Amino Acids or Peptides with Nitroarenes
1407
Palladium-Catalyzed C–H Acylation of Tyrosine-Containing Peptides
1408
Photocatalytic Carbamoylation of Azomethine Imines
1409
Cyclization of ω-Amino Fatty Acids by Reductive Amination of Carbonyl Derivatives
1410
Decarboxylative Propargylic Alkylation: Synthesis of Tetrasubstituted α-Amino Acid Esters
1411
Propargyl Pentafluorophenyl Carbonate as a Coupling Reagent for Peptide Synthesis

Flow Chemistry

z1413
All PDFs of this category
1413
Chlorination of Alkenes under Flow Conditions
1414
Flow Reaction of Cross-Coupling Reaction Between Alkylarenes and Aldehydes
1415
Preparation and Utilization of N-Chloroamines under Continuous Flow