Download PDF
Synfacts 2023; 19(05): 0521
DOI: 10.1055/s-0042-1752485
Peptide Chemistry

Ir-Catalyzed Enantio- and Diastereoselective Synthesis of 3-Substituted Proline Derivatives

Contributor(s):
Hisashi Yamamoto
,
Tomohiro Hattori
Che C, Lu Y.-N, Wang C.-J. * Wuhan University and Nankai University, Tianjin, P. R. of China
Enantio- and Diastereoselective De Novo Synthesis of 3-Substituted Proline Derivatives via Cooperative Photoredox/Brønsted Acid Catalysis and Epimerization.

J. Am. Chem. Soc. 2023;
145: 2779-2786
CrossrefPubMedSearch in Google Scholar
› Further Information
 
 PDF Download Permissions and Reprints

Key words

iridium catalysis - enantioselectivity - diastereoselectivity - 3-substituted prolines - photoredox reaction

Significance

Peptides, including proline, are ubiquitous in biologically active molecules due to their unique structure. The Authors have developed a synthesis of diastereo- and enantioselective proline derivatives.


#

Comment

The synthesis of proline derivatives was undergone by the help of iridium catalysis to afford various types of 3-substituted prolines in high to excellent yields with great diastereo- and enantioselectivity.


#
#

Publication History

Article published online:
14 April 2023

© 2023. Thieme. All rights reserved

Georg Thieme Verlag KG
Rüdigerstraße 14, 70469 Stuttgart, Germany


   Permissions and Reprints