Enantioselective Copper-Catalyzed Three-Component Synthesis of Z,Z-Multifunctional-1,5-dienes

Key words

copper catalysis - allyboration - asymmetric catalysis - allenes

Significance

The group of Fañanás-Mastral reports a highly chemo-, regio-, enantio- and diastero­selective copper-catalyzed synthesis of multifunctional internal 1,5-dienes. This reaction has a large functional group tolerance and the products could be easily transformed into more complex structure for example using coupling reactions.

Comment

The authors explain the high level of enantio- and diasteroselectivity observed in this transformation by non-convalent substrate–ligand interactions. This result is supported by DFT calculations.

Publication History

Article published online:
16 June 2023