DOI: 10.1055/s-00000131

Synfacts

Issue 07 · Volume 19 · July 2023 DOI: 10.1055/s-013-57728

Synform

A114
Zanda, Matteo: SYNFORM ISSUE 2023/07

Synthesis of Natural Products

z0637
All PDFs of this category
0637
Syntheses of (–)-Scabrolide A and (–)-Yonarolide
0638
Total Synthesis of (+)-Ineleganolide
0639
Total Synthesis of (–)-Daphnezomine A
0640
Synthesis of (±)-KB343
0641
Synthesis of (+)-Pedrolide
0642
Total Synthesis of (–)-Grayanotoxin II
0643
Synthesis of (–)-Aspidophytine

Synthesis of Heterocycles

z0645
All PDFs of this category
0645
Aryl Radicals as XAT Promotors Enable Modular Alkyl Iodide Functionalization
0646
Synthesis of Azabicyclic Cores of the Izidine Alkaloids
0647
Ion-Paired Rhodium-Catalyzed Enantioselective Aziridination of Alkenyl Alcohols
0648
Three-Component Reaction for the Synthesis of Isoxazoles
0649
Stereoselective Synthesis of Six-to Eight-Membered Cyclic Ethers through Homologation/Metathesis
0650
A Magical Rearrangement of Aryl Peroxyoxindoles to 1,3-Benzooxazin-4-ones
0651
Cascade Reaction with Preservation of Stereochemistry for the Synthesis of Fused Cyclic Amine Systems
0652
Synthesis of Functionalized Bicyclic Tetrahydrocyclopentafuran Derivatives
0653
Operationally Simple Dearomatization of Bicyclic Azaarenes
0654
Robust Trifluoromethylation of (Hetero)arylboronic Acid Pinacol Esters
0655
Site Selective C–H Carboxylation of N-Heteroarenes via Electrochemical Reactors

Synthesis of Materials and Unnatural Products

z0657
All PDFs of this category
0657
Pyrenylenes of Varied Size from One Pot
0658
Chiral Bowl-Shaped PAHs with Five- and Eight-Membered Rings
0659
A One-Pot Method from Six- to Seven-Membered Rings
0660
Dearomatization of Quinolines and Isoqunolines
0661
π-Extended Chiral [2.2]Cyclophanes
0662
A Chiral Calix[3]pyrrole Analogue
0663
Heptacene Analogue with Benzodi[7]annulene
0664
Pot-Economic Approach to Benzophenanthridine Alkaloids
0665
Stochastic Bullvalene Architecture Modulates Structural Rigidity in π-Rich Macromolecules
0666
Functionalizing COFs via Ugi Reaction
0667
Recyclable and Malleable Polycyanurate Thermosets
0668
A Modular Strategy for N-Doped PAHs with Nonhexagons

Metals in Synthesis

z0669
All PDFs of this category
0669
An Asymmetric Intramolecular Heck-Type Reaction of in situ Generated Hydrazones
0670
Enantioconvergent Trifluoromethoxylation of Propargyl Sulfonates under Copper Catalysis
0671
Enantioselective Copper-Catalyzed Three-Component Synthesis of Z,Z-Multifunctional-1,5-dienes
0672
Metal-Controlled Regiodivergent Hydroamination of α-Methylene-β-Lactams
0673
Nickel-Catalyzed Asymmetric Vinylogous Addition of Silyloxyfuran to Oxindoles
0674
Cobalt-Catalyzed Hydroalkylation of Glycals for the Stereoselective Synthesis of 2-Deoxy-β-C-Glycosides
0675
Gone in 60 Seconds: Very Fast Birch Reductions under Ammonia-Free Conditions Using Ball-Milling Technique
0676
Silver-Catalyzed Formation of Benzo[d]oxepines via Ring-Expansive Addition of Diazonium Compounds
0677
Terminating the Catellani Reaction by C(sp2)–I Reductive Elimination to Access ortho-Iodobiaryls
0678
Copper/Chromium-Catalyzed Nucleophilic C(sp3)–H Addition of Alkanes to Aldehydes under Visible Light
0679
Cobalt-Catalyzed Reductive Arylation of N-Sulfonyl Imines
0680
Gold-Catalyzed Heck Reaction with Selective β-Hydride Elimination
0681
Asymmetric Metalloradical-Catalyzed Synthesis of Cyclopropane-Fused Chromanes and Chromanones
0682
Functionalized 1,4-Dihydropyridines Using Benzylamines, N,N-Dimethyl Enaminones and Copper
0683
Rhodium-Catalyzed Synthesis of Chiral trans-γ‑Lactams through Dynamic Kinetic Resolution
0684
Turning Enol Triflates into Axially Chiral Allenes by Palladium-Catalyzed Enantioselective β-H Elimination
0685
Cooperative Dihydrogen Activation by a Zinc–Anilide Complex Enables Semi-Hydrogenation of Alkynes
0686
Photoredox-Catalyzed Trifluoromethylation of C(sp2)–H Bonds with Trifluoroacetic Anhydride
0687
β-Selective C(sp3)–H Borylation of Saturated Cyclic Amines and Lactams by Cooperative Catalysis
0688
Palladium-Catalyzed Benzylic Allyl-/Allenylation of Benzyl Chlorides
0689
Sulfamidate Imine Derived 1-Azadienes: A New Class of Dipolarophiles in Pd-Catalyzed [3+2] Cycloadditions
0690
A Ligand-Controlled Stereodivergent Decarboxylative Aldol Reaction under Titanium Catalysis
0691
Z-Retentive Asymmetric Allylation of Oxindoles Using Iridium Catalysis
0692
A General Protocol for Photoinduced C(sp3)–H Functionalization under Iron Catalysis
0693
Enantioconvergent Synthesis of α-Amino Acids by Iron-Catalyzed α-C(sp3)–H Amination of Carboxylic Acids
0694
Synthesis of Functionalized Skipped Dienes via Nickel-Catalyzed Reductive Cross-Coupling
0695
Synthesis of 2,3-Disubstituted Indoles via Palladium-Catalyzed Cyclization of ortho-Alkynyl Anilines

Polymer-Supported Synthesis

z0697
All PDFs of this category
0697
Cross-Dehydrogenative C(sp2)–N Coupling by a Cu–Co Dual-Atom Catalyst Supported on Hierarchical Zeolite
0698
N-Monomethylation of Primary Amines and Nitroarenes with Methanol Using Pd(II) Dispersed on Zn(Al)O
0699
Mechanochemical Suzuki–Miyaura Coupling Promoted by PEG-Supported Palladium Complex
0700
Reductive Amination of Aryl Ethers Catalyzed by Hf-Exchanged Montmorillonite-Supported Pd
0701
Hydroboration of Olefines with a Cobalt(0)-COF Catalyst
0702
Bodipy-Based MOFs Transformed from 1D Chain to 2D Layer as Photocatalysts Build C–B and C–C Bonds
0703
Monophosphine-Ir or -Ru Complexes in Chiral Diphosphine-Based COFs for Asymmetric Hydrogenation
0704
Photo-Induced Borylation of N-Heteroarenes with a β-Keto Enamine-Based Covalent Organic Framework
0705
Ruthenium Phosphide Nanoparticles Supported on SiO2 for Hydrogenation of Sulfur-Containing Nitroarenes
0706
Photocatalytic Oxidative Homo-Coupling of Amines by a Donor–Acceptor Mixed-Ligand MOF
0707
Synthesis of Tetrasubstituted Pyridines through Solid-Phase Truce–Smiles Rearrangement
0708
C–H Oxidation and Epoxidation of Alkenes Using a FeIII–MOF-253 Complex with O2

Organo- and Biocatalysis

z0709
All PDFs of this category
0709
Engineered Methyltransferase-Catalyzed Terminal Prenyl Group Tail Methylation of Linear Terpenoids
0710
BINOL Catalysis Permits One-Pot Synthesis of Chiral Trifluoromethyl and Trimethylsilyl Allenols
0711
Asymmetric Conjugate Hydrocyanation of Enals via SET-Induced Umpolung
0712
Methionine Sulfoxide Reductase as an Efficient Catalyst for Kinetic Resolution of the Chiral Sulfoxides
0713
Regioselective meta-Amination of Arylamines Enabled by in situ Generated Quinone Imine Ketals
0714
Towards Efficient Synthesis of Chiral β-Amino Amides via Organocatalysis
0715
Novel C2-Symmetric Borinic Acids Expand the Scope of Boron-Based Catalysts for Asymmetric Transformations
0716
Organocatalytic Enantioselective Reductive Radical Coupling of Ketimines with Dihydropyridines
0717
Enantioselective Iminium Catalysis-Mediated Vinylcyclopropane–Cyclopentene Rearrangement

Innovative Drug Discovery and Development

z0719
All PDFs of this category
0719
Conquering Regioselectivity Issues: Scalable Synthesis to an Alkylated 1,2,4-Triazole Building Block
0720
Synthesis of Selective HDAC11 Inhibitor with Nanomolar Potency
0721
Controlling Protein Activity with a Carboxyl Group Cage
0722
A Dearomative Cyclization Approach Enables Easy Access to Cardenolides from the Hajos–Parrish Ketal
0723
Semi-Rational Design Expedites Identification of Imine Reductases with Complementary Enantioselectivity
0724
Discovery of Haloperidol
0725
Efficient Synthesis of Ketoprofen
0726
Practical and Environmentally Friendly Manufacturing Process for Ensitrelvir, a SARS-CoV-2 Antiviral Candidate
0727
Discovery of a Potent and Orally Bioavailable Estrogen Receptor Degrader-Antagonists
0728
Synthesis of Urazolyl-Tyrosine Macrocyclic Peptides via Chemoselective Oxidative C–N Coupling
0729
Preparation of Biologically Active Peptide-Isoquinolone Conjugates

Peptide Chemistry

z0731
All PDFs of this category
0731
C–H Functionalization for the Synthesis of Maleimide-Decorated Peptides and Macrocyclic Peptides
0732
Regioselective Fluorination of Amino Acid Derivatives
0733
Electrosynthesis of γ,δ-Unsaturated α-Amino Esters
0734
Pd-Catalyzed α-Allylation of N-Unprotected Amino Acids
0735
One-Pot Synthesis of Amnio Acids with Consecutive Tetrasubstituted Stereogenic Center
0736
Asymmetric Alkylation to Afford Tetrasubstituted Amino Acids
0737
Copper-Catalyzed Synthesis of α-Amino Acids from Primary Alcohols
0738
Selective Deprotection of tert-Butyl Ester Groups in N-Boc-Protected Amino Acid tert-Butyl Esters

Flow Chemistry

z0739
All PDFs of this category
0739
Enantioselective Synthesis of α-Alkylated Aldehydes Using Continuous Flow Chemistry and Visible Light