Download PDF
Synfacts 2023; 19(03): 0311
DOI: 10.1055/s-0042-1753295
Peptide Chemistry

Cu-Catalyzed Introduction of Oxime Ethers into Peptides

Contributor(s):
Hisashi Yamamoto
,
Tomohiro Hattori
Liu Y, He Z, Ma W, Bao G, Li Y, Yu C, Li J, R. E Xu Z, *, Wang R, *, Sun W. * Lanzhou University, P. R. of China
Copper(I)-Catalyzed Late-Stage Introduction of Oxime Ethers into Peptides at the Carboxylic Acid Site.

Org. Lett. 2022;
24: 9284-9253
CrossrefPubMedSearch in Google Scholar
› Further Information
 
 PDF Download Permissions and Reprints

Key words

copper catalysis - oxime ethers - late-stage functionalization

Significance

For a long time, the development of late-stage modifications to peptides has been an important endeavor to organic chemists. In this study the authors have successfully demonstrated a copper-catalyzed introduction of oxime ethers to peptides.


#

Comment

This copper catalysis is a promising method for the introduction of biological fragments into peptides. This method was successfully performed with various peptides in excellent yields.


#
#

Publication History

Article published online:
13 February 2023

© 2023. Thieme. All rights reserved

Georg Thieme Verlag KG
Rüdigerstraße 14, 70469 Stuttgart, Germany


   Permissions and Reprints