Liu Y,
He Z,
Ma W,
Bao G,
Li Y,
Yu C,
Li J,
R. E
Xu Z,
*,
Wang R,
*,
Sun W.
*
Lanzhou University, P. R. of China
Copper(I)-Catalyzed Late-Stage Introduction of Oxime Ethers into Peptides at the Carboxylic Acid Site.
Org. Lett. 2022;
24: 9284-9253
Key words
copper catalysis - oxime ethers - late-stage functionalization
Significance
For a long time, the development of late-stage modifications to peptides has been an important endeavor to organic chemists. In this study the authors have successfully demonstrated a copper-catalyzed introduction of oxime ethers to peptides.
Comment
This copper catalysis is a promising method for the introduction of biological fragments into peptides. This method was successfully performed with various peptides in excellent yields.
