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Synfacts 2023; 19(03): 0311
DOI: 10.1055/s-0042-1753295
Peptide Chemistry

Cu-Catalyzed Introduction of Oxime Ethers into Peptides

Rezensent(en):
Hisashi Yamamoto
,
Tomohiro Hattori
Liu Y, He Z, Ma W, Bao G, Li Y, Yu C, Li J, R. E Xu Z, *, Wang R, *, Sun W. * Lanzhou University, P. R. of China
Copper(I)-Catalyzed Late-Stage Introduction of Oxime Ethers into Peptides at the Carboxylic Acid Site.

Org. Lett. 2022;
24: 9284-9253
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Key words

copper catalysis - oxime ethers - late-stage functionalization

Significance

For a long time, the development of late-stage modifications to peptides has been an important endeavor to organic chemists. In this study the authors have successfully demonstrated a copper-catalyzed introduction of oxime ethers to peptides.


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Comment

This copper catalysis is a promising method for the introduction of biological fragments into peptides. This method was successfully performed with various peptides in excellent yields.


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Publikationsverlauf

Artikel online veröffentlicht:
13. Februar 2023

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