RSS-Feed abonnieren
Bitte kopieren Sie die angezeigte URL und fügen sie dann in Ihren RSS-Reader ein.
https://www.thieme-connect.de/rss/thieme/de/10.1055-s-00000131.xml
Synfacts 2023; 19(04): 0357
DOI: 10.1055/s-0042-1753425
DOI: 10.1055/s-0042-1753425
Metals in Synthesis
ortho Difunctionalization of Arenes by Iron/Titanium Synergistic Interaction
Wei Y.-M,
Ma X.-D,
Wang M.-F,
Duan X.-F.
*
Beijing Normal University, P. R. of China
Synergism of Fe/Ti Enabled Regioselective Arene Difunctionalization.
J. Am. Chem. Soc. 2023;
145: 1542-1547
DOI: 10.1021/jacs.2c13207
Synergism of Fe/Ti Enabled Regioselective Arene Difunctionalization.
J. Am. Chem. Soc. 2023;
145: 1542-1547
DOI: 10.1021/jacs.2c13207
Significance
Duan and co-workers report an ortho difunctionalization of arenes through an unusual 1,2-aryl heterobimetallic Fe/Ti intermediate. This strategy allows facile access to ortho-difunctionalized arenes in a regioselective manner.
#
Comment
The ferration process can be formally regarded as a C–Ti bond-directed ortho metalation (DOM). The regioselectivity of the ferration was shown to be dependent either on steric effects or the presence of an iron-chelating atom acting as a directing group (see gray box).
#
#
Publikationsverlauf
Artikel online veröffentlicht:
17. März 2023
© 2023. Thieme. All rights reserved
Georg Thieme Verlag KG
Rüdigerstraße 14, 70469 Stuttgart, Germany