DOI: 10.1055/s-00000131

Synfacts

Issue 04 · Volume 19 · April 2023 DOI: 10.1055/s-013-56992

Synform

A59
Zanda, Matteo: SYNFORM ISSUE 2023/04

Synthesis of Natural Products

z0323
All PDFs of this category
0323
Synthesis of (+)-Chejuenolide A
0324
Total Synthesis of (–)-Taxol
0325
Total Synthesis of (+)-Bufogargarizin B
0326
Total Synthesis of (–)-Prorocentin
0327
Synthesis of (–)-Lissodendoric acid A
0328
Synthesis of Atrachinenins A and B
0329
Total Synthesis of (–)-Strychnine

Synthesis of Heterocycles

z0331
All PDFs of this category
0331
Modular Synthesis of Benzimidazoles from Nitroarenes
0332
Oxidant-Free Synthesis of Fully Substituted Pyrroles through Multicomponent Cyclization
0333
Circumventing the Aryldiazonium Salt Isolation in Intramolecular Heck–Matsuda Coupling
0334
Direct and Practical Approach for the Synthesis of δ-Carbolines and Benzofuro[3,2-b]pyridines
0335
Rational Design of a Palladium Catalyst System for C–N Bond Formation of Five-Membered Heteroaryl Halides
0336
Robust Conditions for Nickel-Catalyzed Suzuki–Miyaura Cross-Couplings of Complex Molecules
0337
Palladium-Catalyzed Synthesis of Benzazocines via [6+2] Double Allene Annulation
0338
Catalyst-Free Synthesis of Oxacyclic Spirooxindoles through Oxonium Ylide Mediated Ring Expansion
0339
Scalable Syntheses of Functionalized 2-Oxabicyclo[2.2.2]octanes
0340
Construction of Functionalized Oxazole via Three-Component Cyclization Using a Lewis Acid
0341
Bicyclic Silaazacycles Featuring Silicon at the Ring Junction: Synthesis and Further Transformations
0342
Nickel-Catalyzed One-Pot Cascade Synthesis of N‑Substituted Indoles
0343
Three-Step Modular Synthesis of N-Substituted Bicyclic Systems
0344
Efficient Access to Pharmacologically Relevant 2-Arylpiperazines

Synthesis of Materials and Unnatural Products

z0345
All PDFs of this category
0345
9-Fluorenol-Assisted Tertiary Radical Generation and Functionalization
0346
Build-Up BN-Rings Step by Step
0347
Catenation of Chiral Cubes
0348
Double Annulation with Three C–C Bond Formations
0349
“Click” a Phenanthrene
0350
Three-Component Synthesis of Bicyclic Diphosphacycles
0351
B(III)Br-B(II)-Stabilized Neutral Boryl Radical
0352
Carbene-Mediated Polyaminoborane Depolymerization
0353
How Does 5+7 Compare to 6+6
0354
Desymmetrized Chiral Calix[4]arenes
0355
Aromatic Ring Expansions by Iminosilylene
0356
o-Nitrobenzyl Ether-Enabled Polymer Photo-Degradation

Metals in Synthesis

z0357
All PDFs of this category
0357
ortho Difunctionalization of Arenes by Iron/Titanium Synergistic Interaction
0358
Enantioselective Molybdenum-Catalyzed Cyclopropanation via Carbonyl Activation
0359
Ni-Catalyzed Formation of Two Vicinal Enantioenriched C(sp3) Centers Stemming from Two Starting Materials
0360
Enantioselective Rhodium-Catalyzed Synthesis of Cyclobutene Derivatives Using Boronic Acids
0361
Enantioselective Copper-Catalyzed Inverse-Electron-Demand Diels–Alder Using Phenyl Vinyl Selenide
0362
Catalytic Asymmetric Conjugate Addition of 1,4-Dienes to β-Substituted Alkenyl Azaarenes
0363
Nickel-Catalyzed Acylzincation of Ynamides with Alkylzinc Reagents Under CO Atmosphere
0364
Photoinduced Decarboxylative C–C and C–N Couplings of Carboxylic Acids under Dual Iron/Copper Catalysis
0365
Synthesis of Oxaspirolactones via Palladium-Catalyzed Hydrocarbonylation of Alcohol-Tethered Styrenes
0366
Enantioselective Cobalt-Catalyzed Double Hydrogenation for Chiral Z-Allylamide Syntheses
0367
Iron-Catalyzed and Electrochemical Dehydrogenative Synthesis of Monofluorinated Oxindoles
0368
Copper-Catalyzed Benzo[d][1,3,2]dithiazole-1-oxide Synthesis via Cross-Coupling with Elemental Sulfur
0369
Copper-Catalyzed Addition of Terminal Alkynes across Dialkyl Azodicarboxylates
0370
Syntheses of Difluorocarbonyl Oxindoles and Isoquinoline-1,3-diones via Radical Nickel Catalysis
0371
Asymmetric α-Acylation of N-Heterocycles with Carboxylic Acids by Dual Nickel/Photoredox Catalysis
0372
Nickel-Catalyzed Regiodivergent Cross-Electrophile Coupling of Alkyl Bromides Steered by the Ligand
0373
Photocatalytic C(sp2)−H Fluoromethoxylation of Arenes
0374
Silver-Catalyzed Synthesis of Spirocycles via an Enamine–Iminium Umpolung Step
0375
Gold-Catalyzed Synthesis of Alkynylated Pyrrolidines from N,O-Acetals via Cyclic Iminium Ion Intermediates
0376
Synthesis of Pyrrolines via Ni-Catalyzed Iminoarylation of Alkene-Tethered Oxime Esters
0377
Enantioconvergent Cross-Electrophile Coupling of Two Alkyl Halides to Access Chiral α-Alkylboronic Esters
0378
Stereoconvergent 1,3-Rearrangement of (Homo)Allylic Alcohols Using Crabtree’s Catalyst
0379
Nickel-Catalyzed Enantioselective C(sp)–P Cross-Coupling of Secondary Phosphines with Bromoalkynes
0380
Highly Linear- or Branched-Selective Ni-Catalyzed Mizoroki–Heck Reaction of 1,3-Dienes
0381
Intercepted Kinugasa Reaction with Ir Catalysis: Asymmetric Synthesis of Allylated β-Lactams
0382
Desymmetrization of 1,3-Diols by Copper(I)-Catalyzed S–O Cross-Coupling with Aryl Sulfonyl Chlorides

Polymer-Supported Synthesis

z0383
All PDFs of this category
0383
Semi-Hydrogenation of Alkynes and Suzuki Coupling with a Polyurethane Foam-Supported Pd Catalyst
0384
C3-Formylation of Indoles with Methanol by g-C3N4/rGO/BiVO4 Heterojunction Photocatalyst
0385
MOF-Supported Chiral Frustrated Lewis Pair for Asymmetric Hydrogenation
0386
Photocatalytic Dehydrative Etherification of Alcohols by an Unsupported Nanoporous Gold Catalyst
0387
Aerobic Oxidative Annulation of N-Arylpyrrolidines Catalyzed by Pt/C
0388
Synthesis of Amino Phenazines through the Oxidative Cyclization of Anilines with o-Phenylenediamines
0389
1,4-Arylation of α,β-Unsaturated Ketones with Arylboronic Acids Using NHC–Coordinated Rh on Ceria
0390
Heterogeneous Photocatalytic Multicomponent Reaction for the Synthesis of Imidazolidines
0391
Hydrogenation of Nitroarenes Catalyzed by a COF-Based Photocatalyst
0392
Oxidative Coupling of Carbon Monoxide with Amines by Gold Nanoparticles Supported on ZnO
0393
Synthesis of α‑Haloketones from Vinylarenes Catalyzed by Cu-Modified Graphitic Carbon Nitride
0394
Asymmetric Allylic Amination Using PS-Supported Phosphoramidite Ligands–Ir Complex

Organo- and Biocatalysis

z0395
All PDFs of this category
0395
Formal Electronically Mismatched Radical Additions
0396
Carbene Transferases as Catalysts for Chemodivergent Activation of C(sp2)–H and C(sp3)–H Bonds
0397
Enantioselective Synthesis of Tertiary Nitroalkanes Enabled by Enzyme Catalysis
0398
Aminocatalytic Enantio-, Diastereo- and Periselective [4+4] Cycloaddition
0399
Hydrogen-Bond-Donor Catalyst Permits Asymmetric Transformation of Sulfonyl Cyanides toward Sulfinates
0400
Photocatalytic Cyclopropanation of Unactivated Olefins with α-Bromomalonates and α-Bromo-β-Keto Esters
0401
Borenium-Catalyzed Hydrogenative Cleavage of Unactivated C(Aryl)–C(Alkyl) Bonds
0402
Conformation-Switching DNA Photocatalyst for Radical Polymerization
0403
Asymmetric Enolexo-Aldol Condensations of Siladials via Enamine Catalysis
0404
Identification of a Pericyclase that Catalyzes the Formation of cis-Decalins

Innovative Drug Discovery and Development

z0405
All PDFs of this category
0405
Bioorthogonal “Click-and-Release” of Iminosydnones to Give Water-Stable Isocyanates
0406
Total Synthesis of Iridoid Oligomers Enlightens Efficacy of Folk Medicine
0407
Process Understanding Enables Control of Hydrogen Fluoride Formation in a Nitroarene Reduction
0408
Hydrolysis-Resistant Ester for Probe Development
0409
Design and Synthesis of BCL6 BTB Inhibitor OICR12694
0410
MK-8189: A Potent and Selective PDE10A Inhibitor for the Treatment of Schizophrenia
0411
Photo-Decarboxylative Coupling of α-Amino Acids and Enones Enables Efficient Synthesis of a Drug Scaffold
0412
A Scalable Asymmetric Total Synthesis of (–)-Emetine
0413
Efficient Synthesis of DNA Interstrand Cross-Links
0414
Stepwise, Controllable Electrochemical Reduction of Trifluoromethylarenes
0415
Macrocyclization and Scaffold Hopping Improves Selectivity and ADME Properties of HPK1 Inhibitors
0416
Synthesis of Anesthetic Ketamine

Peptide Chemistry

z0417
All PDFs of this category
0417
Rh(III)-Catalyzed Synthesis of Unnatural Peptides
0418
Coupling of Amino Acid Terminal Alkyne with in situ Iminium Ion to Access Nε‑Substituted Lysine Mimetics
0419
Visible-Light-Mediated Continuous-Flow Technology for the Synthesis of α-(N-Hydroxy)amino Amides
0420
Modification of Diamino Acid-Containing Hydrospirophosphoranes
0421
Acetoxylation of Tyrosine-Containing Peptides Using a Palladium Catalyst
0422
Palladium-Catalyzed C–H Alkenylation to Form Maleimide-Braced Peptides
0423
Organocatalyzed Enantioselective N–H Insertion
0424
Synthesis of N-Formyl Amino Acid Esters

Flow Chemistry

z0425
All PDFs of this category
0425
Segmented Continuous Flow Allows for Convenient Synthesis of Phenyl Glucosazone

Erratum

0426
Wang, F; Fu, R; Chen, J; Rong, J; Wang, E; Zhang, J; Zhang, Z; Jiang, Y: Erratum: 2-Amino-3,3-difluoro-2,3-dihydrofurans from Difluorocarbenes and Enaminones